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Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Institute of Infectious Disease and Molecular Medicine
2014
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| _version_ | 1867613189171052544 |
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| access_status_str | Open Access |
| author | Hurdayal, Ramona |
| author2 | Brombacher, Frank |
| author_browse | Brombacher, Frank Hurdayal, Ramona |
| author_facet | Brombacher, Frank Hurdayal, Ramona |
| author_sort | Hurdayal, Ramona |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3059 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:11.035Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Institute of Infectious Disease and Molecular Medicine |
| publisherStr | Institute of Infectious Disease and Molecular Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3059 Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection Hurdayal, Ramona Brombacher, Frank Revaz-Breton, Melanie Includes abstract. Includes bibliographical references. In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses and the production of interleukin (IL)-4 and IL-13, which share a common receptor subunit, the IL-4 receptor alpha chain (IL-4α ). While IL-4 is the main inducer of Th2 responses, paradoxically it has been shown that exogenously administered IL-4 can promote dendritic cell IL-12 production and enhance Th1 development if given early during infection. 2014-07-28T14:49:11Z 2014-07-28T14:49:11Z 2013 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3059 eng application/pdf Institute of Infectious Disease and Molecular Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Hurdayal, Ramona Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection |
| thesis_degree_str | Doctoral |
| title | Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection |
| title_full | Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection |
| title_fullStr | Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection |
| title_full_unstemmed | Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection |
| title_short | Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection |
| title_sort | deletion of il 4 receptor alpha on dendritic cells renders balb c mice hypersusceptible to leishmania major infection |
| url | http://hdl.handle.net/11427/3059 |
| work_keys_str_mv | AT hurdayalramona deletionofil4receptoralphaondendriticcellsrendersbalbcmicehypersusceptibletoleishmaniamajorinfection |