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An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Molecular and Cell Biology
2014
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| _version_ | 1867613190921125888 |
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| access_status_str | Open Access |
| author | Chang, Ju-Wei |
| author2 | Davids, Lester M |
| author_browse | Chang, Ju-Wei Davids, Lester M |
| author_facet | Davids, Lester M Chang, Ju-Wei |
| author_sort | Chang, Ju-Wei |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3067 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:13.078Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3067 An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing Chang, Ju-Wei Davids, Lester M Cell Biology Includes abstract. Includes bibliographical references. On healing, partial-thickness burn wounds usually result in depigmentation of the skin. This is due to the loss of melanocytes. The lack of pigmentation in the healed wound is particularly prominent in dark-skinned individuals and could result in serious psychosocial consequences such as low self-esteem, stigmatisation and discrimination among sufferers. Methods aimed at investigating rapid and efficient repigmentation in wounded skin are therefore pertinent. The aims of this study were two-fold: i) To promote melanin synthesis in human skin cells using different ratios of human melanocytes (Mc) to keratinocytes (Kc) in an in vitro co-culture system, in order to ensure pigmentation of the skin and, ii) To understand cellular mechanisms that contribute basic scientific knowledge towards clinically improved wound healing. 2014-07-28T14:50:22Z 2014-07-28T14:50:22Z 2013 Master Thesis Masters MSc http://hdl.handle.net/11427/3067 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Chang, Ju-Wei An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing |
| thesis_degree_str | Master's |
| title | An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing |
| title_full | An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing |
| title_fullStr | An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing |
| title_full_unstemmed | An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing |
| title_short | An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing |
| title_sort | in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co cultures to improve wound healing |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/3067 |
| work_keys_str_mv | AT changjuwei aninvitroinvestigationintothepigmentaryphenotypeofmelanocytesandkeratinocytecoculturestoimprovewoundhealing AT changjuwei invitroinvestigationintothepigmentaryphenotypeofmelanocytesandkeratinocytecoculturestoimprovewoundhealing |