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Network generation and analysis for the investigation of host-pathogen interactions in tuberculosis Holifidy Arisoa Rapanoel.
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| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2014
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| _version_ | 1867613205340094464 |
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| access_status_str | Open Access |
| author | Rapanoel Holifidy Arisoa |
| author2 | Mulder, Nicola |
| author_browse | Mulder, Nicola Rapanoel Holifidy Arisoa |
| author_facet | Mulder, Nicola Rapanoel Holifidy Arisoa |
| author_sort | Rapanoel Holifidy Arisoa |
| collection | Thesis |
| description | Scroll down to electronic link to access the thesis. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3074 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:26.116Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3074 Network generation and analysis for the investigation of host-pathogen interactions in tuberculosis Holifidy Arisoa Rapanoel. Rapanoel Holifidy Arisoa Mulder, Nicola Scroll down to electronic link to access the thesis. Includes abstract. Includes bibliographical references. This project aims to predict protein interactions between human and Mtb. The interologs method based on experimentally verified intra-species and inter-species interactions was used to predict human-Mtb protein interactions. They were further filtered using known host-pathogen interactions and genes that are differentially expressed during infection. This yielded a total of 190 interactions. Analysis of the subcellular location of the human-Mtb interactions showed that they are potentially feasible. The biological processes of the predicted human proteins suggested their involvement in apoptosis and production of nitric oxide, whereas those of the Mtb proteins were relevant to the intracellular environment of Mtb in the host. 2014-07-28T14:50:35Z 2014-07-28T14:50:35Z 2012 Master Thesis Masters MSc http://hdl.handle.net/11427/3074 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Rapanoel Holifidy Arisoa Network generation and analysis for the investigation of host-pathogen interactions in tuberculosis Holifidy Arisoa Rapanoel. |
| thesis_degree_str | Master's |
| title | Network generation and analysis for the investigation of host-pathogen interactions in tuberculosis Holifidy Arisoa Rapanoel. |
| title_full | Network generation and analysis for the investigation of host-pathogen interactions in tuberculosis Holifidy Arisoa Rapanoel. |
| title_fullStr | Network generation and analysis for the investigation of host-pathogen interactions in tuberculosis Holifidy Arisoa Rapanoel. |
| title_full_unstemmed | Network generation and analysis for the investigation of host-pathogen interactions in tuberculosis Holifidy Arisoa Rapanoel. |
| title_short | Network generation and analysis for the investigation of host-pathogen interactions in tuberculosis Holifidy Arisoa Rapanoel. |
| title_sort | network generation and analysis for the investigation of host pathogen interactions in tuberculosis holifidy arisoa rapanoel |
| url | http://hdl.handle.net/11427/3074 |
| work_keys_str_mv | AT rapanoelholifidyarisoa networkgenerationandanalysisfortheinvestigationofhostpathogeninteractionsintuberculosisholifidyarisoarapanoel |