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The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Anatomical Pathology
2014
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| _version_ | 1867613261757677568 |
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| access_status_str | Open Access |
| author | Langman, Gerald |
| author2 | Hall, Pauline de la Motte |
| author_browse | Hall, Pauline de la Motte Langman, Gerald |
| author_facet | Hall, Pauline de la Motte Langman, Gerald |
| author_sort | Langman, Gerald |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3082 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:19.547Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Anatomical Pathology |
| publisherStr | Division of Anatomical Pathology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3082 The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury Langman, Gerald Hall, Pauline de la Motte Anatomical Pathology Includes bibliographical references. Hepatoxicity, especially liver fibrosis. is the major concern with long-term, low-dose oral methotrexate (MTX) therapy for psoriasis. The histological features are nonspecific and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver injury are also associated with NASH. In this study serial liver biopsies of 24 psoriatic patients on lOng-term MTX were investigated to determine whether they had risk factors for NASH and the histological features of a NASH-like pattern of liver injury that could have been contributing to the prevalence and progression of liver injury that occurred while on MTX. 2014-07-28T14:51:42Z 2014-07-28T14:51:42Z 2001 Master Thesis Masters MMed http://hdl.handle.net/11427/3082 eng application/pdf Division of Anatomical Pathology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Anatomical Pathology Langman, Gerald The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury |
| thesis_degree_str | Master's |
| title | The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury |
| title_full | The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury |
| title_fullStr | The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury |
| title_full_unstemmed | The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury |
| title_short | The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury |
| title_sort | role of non alcoholic steatohepatitis nash in methotrexate induced liver injury |
| topic | Anatomical Pathology |
| url | http://hdl.handle.net/11427/3082 |
| work_keys_str_mv | AT langmangerald theroleofnonalcoholicsteatohepatitisnashinmethotrexateinducedliverinjury AT langmangerald roleofnonalcoholicsteatohepatitisnashinmethotrexateinducedliverinjury |