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A systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children
The World Health Organisation (WHO) recommends the introduction of at least one single dose of inactivated polio vaccine (IPV) in routine immunisation schedules to mitigate the risk of a polio virus type 2 reintroduction or re-emergence. As a result, there has been an increased demand and concurrent...
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| Format: | Thesis |
| Language: | English |
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Department of Public Health and Family Medicine
2020
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| _version_ | 1867613890630647808 |
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| access_status_str | Open Access |
| author | Mashunye, Thandiwe Runyararo |
| author2 | Wiysonge, Shey S |
| author_browse | Mashunye, Thandiwe Runyararo Wiysonge, Shey S |
| author_facet | Wiysonge, Shey S Mashunye, Thandiwe Runyararo |
| author_sort | Mashunye, Thandiwe Runyararo |
| collection | Thesis |
| description | The World Health Organisation (WHO) recommends the introduction of at least one single dose of inactivated polio vaccine (IPV) in routine immunisation schedules to mitigate the risk of a polio virus type 2 reintroduction or re-emergence. As a result, there has been an increased demand and concurrent supply shortages of IPV worldwide resulting in poor access to IPV. With the phasing out of the oral polio vaccine and the pursuit of global eradication of polio, ensuring an adequate supply of IPV is of paramount importance. One of the strategies to improve access is the use of the fractional dose because of its dose sparing and cost reduction properties. This mini-dissertation presents a research protocol (Section A), scoping review (Section B) and journal formatted manuscript (Section C) for a systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children. Section A describes the rationale for the review, eligibility criteria, the search strategy and methods for data extraction and analysis. Section B is a scoping review that details the journey towards eradication of polio, the current state of IPV demand and supply and further explains the rationale for performing the systematic review. Section C is a manuscript that gives the results of the review after performing the methods outlined in Section A. The results showed that as the number of IPV doses increased the seroconversion rates for fractional dose and full dose IPV approximated each other such that at three doses the rates were similar. In conclusion, there is no difference in seroconversion between three doses of fractional dose IPV and three doses of full dose IPV. With the current IPV shortages, using fractional dose IPV instead of the full dose IPV can stretch supplies and possibly lower the cost of polio vaccination. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/30931 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:43:20.457Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/30931 A systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children Mashunye, Thandiwe Runyararo Wiysonge, Shey S Ndwandwe, Duduzile E Epidemiology and Biostatistics Specialization The World Health Organisation (WHO) recommends the introduction of at least one single dose of inactivated polio vaccine (IPV) in routine immunisation schedules to mitigate the risk of a polio virus type 2 reintroduction or re-emergence. As a result, there has been an increased demand and concurrent supply shortages of IPV worldwide resulting in poor access to IPV. With the phasing out of the oral polio vaccine and the pursuit of global eradication of polio, ensuring an adequate supply of IPV is of paramount importance. One of the strategies to improve access is the use of the fractional dose because of its dose sparing and cost reduction properties. This mini-dissertation presents a research protocol (Section A), scoping review (Section B) and journal formatted manuscript (Section C) for a systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children. Section A describes the rationale for the review, eligibility criteria, the search strategy and methods for data extraction and analysis. Section B is a scoping review that details the journey towards eradication of polio, the current state of IPV demand and supply and further explains the rationale for performing the systematic review. Section C is a manuscript that gives the results of the review after performing the methods outlined in Section A. The results showed that as the number of IPV doses increased the seroconversion rates for fractional dose and full dose IPV approximated each other such that at three doses the rates were similar. In conclusion, there is no difference in seroconversion between three doses of fractional dose IPV and three doses of full dose IPV. With the current IPV shortages, using fractional dose IPV instead of the full dose IPV can stretch supplies and possibly lower the cost of polio vaccination. 2020-02-07T13:44:21Z 2020-02-07T13:44:21Z 2019 2020-02-03T10:58:24Z Master Thesis Masters MPH http://hdl.handle.net/11427/30931 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences |
| spellingShingle | Epidemiology and Biostatistics Specialization Mashunye, Thandiwe Runyararo A systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children |
| thesis_degree_str | Master's |
| title | A systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children |
| title_full | A systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children |
| title_fullStr | A systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children |
| title_full_unstemmed | A systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children |
| title_short | A systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children |
| title_sort | systematic review and meta analysis of fractional dose compared to standard dose inactivated polio vaccination in children |
| topic | Epidemiology and Biostatistics Specialization |
| url | http://hdl.handle.net/11427/30931 |
| work_keys_str_mv | AT mashunyethandiwerunyararo asystematicreviewandmetaanalysisoffractionaldosecomparedtostandarddoseinactivatedpoliovaccinationinchildren AT mashunyethandiwerunyararo systematicreviewandmetaanalysisoffractionaldosecomparedtostandarddoseinactivatedpoliovaccinationinchildren |