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Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Human Genetics
2014
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| _version_ | 1867613275310522368 |
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| access_status_str | Open Access |
| author | Meyer, Jacqueline |
| author2 | Ramesar, Raj |
| author_browse | Meyer, Jacqueline Ramesar, Raj |
| author_facet | Ramesar, Raj Meyer, Jacqueline |
| author_sort | Meyer, Jacqueline |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3099 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:33.643Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Human Genetics |
| publisherStr | Division of Human Genetics |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3099 Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort Meyer, Jacqueline Ramesar, Raj Medicine Includes abstract. Includes bibliographical references (leaves 106-120). To date, surgery is the mainstay treatment for HNPCC. Adjuvant chemotherapy and radiotherapy are often used to reduce systemic and locoregional recurrence, respectively, after curative surgical resection. The main chemotherapeutic agent is 5-Fluoroucacil (5-FU). Studies have attempted to elucidate whether the MMR status of a colorectal cancer (CRC) cohort will define a response to 5-FU therapy. However, no difference in long term response or survival after 5-FU treatment between patients with MMR-proficient and MMR-deficient tomours were detected. 2014-07-28T14:52:31Z 2014-07-28T14:52:31Z 2009 Master Thesis Masters MSc http://hdl.handle.net/11427/3099 eng application/pdf Division of Human Genetics Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Meyer, Jacqueline Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort |
| thesis_degree_str | Master's |
| title | Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort |
| title_full | Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort |
| title_fullStr | Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort |
| title_full_unstemmed | Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort |
| title_short | Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort |
| title_sort | pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5 fluorouracil in a south african colorectal cancer cohort |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3099 |
| work_keys_str_mv | AT meyerjacqueline pharmacogenomicprofilingandclarificationoftheroleofthemismatchrepairgenesinresponsetothechemotherapeuticagent5fluorouracilinasouthafricancolorectalcancercohort |