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The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Immunology
2014
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| _version_ | 1867613203561709568 |
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| access_status_str | Open Access |
| author | Marillier, Reece Gerrad |
| author2 | Brombacher, Frank |
| author_browse | Brombacher, Frank Marillier, Reece Gerrad |
| author_facet | Brombacher, Frank Marillier, Reece Gerrad |
| author_sort | Marillier, Reece Gerrad |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3113 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:24.523Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Immunology |
| publisherStr | Division of Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3113 The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation Marillier, Reece Gerrad Brombacher, Frank Immunology Includes abstract. Includes bibliographical references (leaves 117-129). Schistosoma mansoni egg passage through intestinal tissue into the faecal stream is a critical event for completion of the life cycle of the helminth and involves induction of a type 2 immune response, which is necessary for the host’s survival. Where as T cell-specific IL-4Rα has been shown not to be essential for survival, macrophage/neutrophil-specific IL-4 receptor α-deficient mice (LysMIcre L-4Rα-/lox ), mice lacking alternative macrophages (AAMФ), had severe intestine pathology and high endotoxin levels due to poor egg excretion and dysregulated granuloma formation. This resulted in increased mortality. To determine the role of AAMФ in granuloma we aimed to describe S.mansoni egg induced granuloma formation in the presence and absence of AAMФ using LysMcreIL-4Rα-/lox mice. 2014-07-28T14:54:03Z 2014-07-28T14:54:03Z 2008 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3113 eng application/pdf Division of Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Immunology Marillier, Reece Gerrad The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation |
| thesis_degree_str | Doctoral |
| title | The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation |
| title_full | The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation |
| title_fullStr | The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation |
| title_full_unstemmed | The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation |
| title_short | The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation |
| title_sort | role of il 4 and il 13 responsiveness during schistosoma mansoni induced inflammation |
| topic | Immunology |
| url | http://hdl.handle.net/11427/3113 |
| work_keys_str_mv | AT marillierreecegerrad theroleofil4andil13responsivenessduringschistosomamansoniinducedinflammation AT marillierreecegerrad roleofil4andil13responsivenessduringschistosomamansoniinducedinflammation |