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Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies
Includes bibliographical references (leaves 114-142).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Immunology
2014
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| _version_ | 1867613297243586560 |
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| access_status_str | Open Access |
| author | Myburgh, Elmarie |
| author2 | Brombacher, Frank |
| author_browse | Brombacher, Frank Myburgh, Elmarie |
| author_facet | Brombacher, Frank Myburgh, Elmarie |
| author_sort | Myburgh, Elmarie |
| collection | Thesis |
| description | Includes bibliographical references (leaves 114-142). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3114 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:54.099Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Immunology |
| publisherStr | Division of Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3114 Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies Myburgh, Elmarie Brombacher, Frank Immunology Includes bibliographical references (leaves 114-142). Lymphocyte-specific reconstitution of IL-4Ra was recently established by intercrossing lymphocyte-specific human IL-R4a transgenic mice with mIL-4Ra-deficient mice. Human IL-4Ra may bind to mouse yc resulting in a chimeric receptor specific for human IL-4 but not mouse IL-4. This provides us with and inducible IL-4 system. The aim of this study was to investigate in vitro and in vivo characteristics of our novel hlL-4Ra Tg/mIL-4Ra+/- mouse model. 2014-07-28T14:54:04Z 2014-07-28T14:54:04Z 2006 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3114 eng application/pdf Division of Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Immunology Myburgh, Elmarie Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies |
| thesis_degree_str | Doctoral |
| title | Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies |
| title_full | Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies |
| title_fullStr | Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies |
| title_full_unstemmed | Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies |
| title_short | Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies |
| title_sort | lymphocyte specific reconstitution of il 4ra deficient mice characterization and infectious disease studies |
| topic | Immunology |
| url | http://hdl.handle.net/11427/3114 |
| work_keys_str_mv | AT myburghelmarie lymphocytespecificreconstitutionofil4radeficientmicecharacterizationandinfectiousdiseasestudies |