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Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha
Includes bibliographical references (p. 117-127).
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Immunology
2014
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| _version_ | 1867613282820423680 |
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| access_status_str | Open Access |
| author | Nieuwenhuizen, Natalie |
| author2 | Lopata, Andreas |
| author_browse | Lopata, Andreas Nieuwenhuizen, Natalie |
| author_facet | Lopata, Andreas Nieuwenhuizen, Natalie |
| author_sort | Nieuwenhuizen, Natalie |
| collection | Thesis |
| description | Includes bibliographical references (p. 117-127). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3115 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:40.116Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Immunology |
| publisherStr | Division of Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3115 Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha Nieuwenhuizen, Natalie Lopata, Andreas Brombacher, Frank Immunology Includes bibliographical references (p. 117-127). The fish-parasitizing nematode Anisakis pegreffii induces gastrointestinal disease and allergy when ingested by humans, and can cause occupational allergy in seafood processing workers. The present study examines immune and allergic responses to A. pegreffii in wildtype and gene deficient mice, with special focus on interleukin(IL)-4, IL-13, and the IL-4 receptor alpha (IL-4Rα). Experimental murine models of Anisakis infection, Anisakis-induced anaphylaxis and Anisakis-induced dermatitis were established in order to gain insight into the immune responses generated against Anisakis and unravel mechanisms of allergic disease. 2014-07-28T14:54:06Z 2014-07-28T14:54:06Z 2007 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3115 eng application/pdf Division of Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Immunology Nieuwenhuizen, Natalie Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha |
| thesis_degree_str | Doctoral |
| title | Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha |
| title_full | Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha |
| title_fullStr | Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha |
| title_full_unstemmed | Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha |
| title_short | Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha |
| title_sort | immune and allergic responses to anisakis pegreffii with focus on the roles of il 4 il 13 and the il 4 receptor alpha |
| topic | Immunology |
| url | http://hdl.handle.net/11427/3115 |
| work_keys_str_mv | AT nieuwenhuizennatalie immuneandallergicresponsestoanisakispegreffiiwithfocusontherolesofil4il13andtheil4receptoralpha |