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Spatial and temporal regulation of IL4Rα expression
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Immunology
2014
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| _version_ | 1867613216809418752 |
|---|---|
| access_status_str | Open Access |
| author | Smith, Elizabeth M |
| author2 | Brombacher, Frank |
| author_browse | Brombacher, Frank Smith, Elizabeth M |
| author_facet | Brombacher, Frank Smith, Elizabeth M |
| author_sort | Smith, Elizabeth M |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3117 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:37.404Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Immunology |
| publisherStr | Division of Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3117 Spatial and temporal regulation of IL4Rα expression Smith, Elizabeth M Brombacher, Frank Horsnell, William Immunology Includes abstract. In this study, we generated a new mouse model, which allows both inducible and cell-specific deletion and reconstitution of IL-IL4Rα expression. This model has the potential to add a new dimension to our understanding of IL4Rα biology. This has been achieved by using the established Tet System (Goosen and Bujard, 1992) where the crossing of two complementary transgenic mouse lines enable the generation of the final double transgenic model. The first line expresses the transactivator, tTA, from the Tet-Off expression cassette driven by the Vav hemapoeitic specific promoter (Wiesner et al., 2005). 2014-07-28T14:54:09Z 2014-07-28T14:54:09Z 2008 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3117 eng application/pdf Division of Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Immunology Smith, Elizabeth M Spatial and temporal regulation of IL4Rα expression |
| thesis_degree_str | Doctoral |
| title | Spatial and temporal regulation of IL4Rα expression |
| title_full | Spatial and temporal regulation of IL4Rα expression |
| title_fullStr | Spatial and temporal regulation of IL4Rα expression |
| title_full_unstemmed | Spatial and temporal regulation of IL4Rα expression |
| title_short | Spatial and temporal regulation of IL4Rα expression |
| title_sort | spatial and temporal regulation of il4rα expression |
| topic | Immunology |
| url | http://hdl.handle.net/11427/3117 |
| work_keys_str_mv | AT smithelizabethm spatialandtemporalregulationofil4raexpression |