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The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics.
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Immunology
2014
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| _version_ | 1867613235038912512 |
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| access_status_str | Open Access |
| author | Smith, Liezel C |
| author2 | Brombacher, Frank |
| author_browse | Brombacher, Frank Smith, Liezel C |
| author_facet | Brombacher, Frank Smith, Liezel C |
| author_sort | Smith, Liezel C |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3118 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:54.720Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Immunology |
| publisherStr | Division of Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3118 The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. Smith, Liezel C Brombacher, Frank Schwegmann, Anita Immunology Includes abstract. Includes bibliographical references. Leishmania major is a protozoan parasite and infection in the human host causes severe cutaneous Leishmaniasis. The study aims to determine how signaling via the IL-4Rα on CD4+T cells causes susceptibility to L. major. We compared gene expression patterns early during infection in CD4+ T cells in the absence or presence of IL-4Rα signaling. Non-healer BALB/c mice with a deletion of the IL-4Rα on all cells (IL-4Rα-/-) or CD4+ T cells only (iLCKcreIL-4Rαlox/-) and their controls (wild-type (WT) C57BL/6, WT BALB/c and littermate IL-4Rαlox/-) were subcutaneously infected with L. major. As expected, the C57BL/6 “healer” mice produced a predominant TH1 response, whereas the iLCKcreIL-4Rα-/lox mice and susceptible BALB/c mice produced a TH2 response. 2014-07-28T14:54:11Z 2014-07-28T14:54:11Z 2013 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3118 eng application/pdf Division of Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Immunology Smith, Liezel C The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. |
| thesis_degree_str | Doctoral |
| title | The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. |
| title_full | The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. |
| title_fullStr | The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. |
| title_full_unstemmed | The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. |
| title_short | The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. |
| title_sort | role of cd4 t cells in host protective responses against cutaneous leishmaniasis using genome wide transcriptomics |
| topic | Immunology |
| url | http://hdl.handle.net/11427/3118 |
| work_keys_str_mv | AT smithliezelc theroleofcd4tcellsinhostprotectiveresponsesagainstcutaneousleishmaniasisusinggenomewidetranscriptomics AT smithliezelc roleofcd4tcellsinhostprotectiveresponsesagainstcutaneousleishmaniasisusinggenomewidetranscriptomics |