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Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Biochemistry
2014
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| _version_ | 1867613226111336448 |
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| access_status_str | Open Access |
| author | Dzobo, Kevin |
| author2 | Parker, Iqbal |
| author_browse | Dzobo, Kevin Parker, Iqbal |
| author_facet | Parker, Iqbal Dzobo, Kevin |
| author_sort | Dzobo, Kevin |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3125 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:46.693Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3125 Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts Dzobo, Kevin Parker, Iqbal Medical Biochemistry Includes abstract. Includes bibliographical references (leaves 122-157). Stromal cells and the extracellular matrix (ECM) components provide the microenvironment that is pivotal for cell growth, motility, attachment and differentiation. Fibroblasts are some of the cells responsible for the synthesis of most of the extracellular matrix proteins. Type I collagen is the most abundant extracellular matrix protein in the human body and is found in tissues requiring high tensile strength. In this study we investigated the effect of a pre-formed fibroblast-derived extracellular matrix on the expression of type I collagen and associated matrix metalloproteinases in fibroblasts. 2014-07-28T14:54:51Z 2014-07-28T14:54:51Z 2009 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3125 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Dzobo, Kevin Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts |
| thesis_degree_str | Doctoral |
| title | Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts |
| title_full | Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts |
| title_fullStr | Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts |
| title_full_unstemmed | Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts |
| title_short | Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts |
| title_sort | matrix mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/3125 |
| work_keys_str_mv | AT dzobokevin matrixmediatedregulationoftype1collagensynthesisanddegradationinculturedfibroblasts |