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The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity
Bibliography: leaves 123-146.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Medical Biochemistry
2014
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| _version_ | 1867614383816835072 |
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| access_status_str | Open Access |
| author | Fromme, Bernhard Johannes |
| author2 | Millar, Robert |
| author_browse | Fromme, Bernhard Johannes Millar, Robert |
| author_facet | Millar, Robert Fromme, Bernhard Johannes |
| author_sort | Fromme, Bernhard Johannes |
| collection | Thesis |
| description | Bibliography: leaves 123-146. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3129 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:51:10.796Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3129 The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity Fromme, Bernhard Johannes Millar, Robert Medical Biochemistry Bibliography: leaves 123-146. The hypothalamic neuropeptide, gonadotropin releasing hormone (GnRH) perferentially inteacts with GnRH type I receptors on the gonadotropes in the anterior pituitary. Activation of the GnRH receptor is required for the biosynthesis and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH), which regulate reproductive function. Multiple forms of GnRH are present in most vertebrate species and are thought to have physiological functions in addition to regulating pituitary hormone release. The mammalian type I GnRH receptor is proposed to discriminate between endogenous forms of GnRH (King and Millar, 1995). In this thesis the mechanism of the GnRH selectivity by a mammalian type I GnRH receptor is examined at molecular level and previous hypotheses are re-evaluated. 2014-07-28T14:54:56Z 2014-07-28T14:54:56Z 2001 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3129 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Fromme, Bernhard Johannes The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity |
| thesis_degree_str | Doctoral |
| title | The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity |
| title_full | The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity |
| title_fullStr | The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity |
| title_full_unstemmed | The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity |
| title_short | The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity |
| title_sort | role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/3129 |
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