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Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer
Includes bibliographical references (leaves 109-130).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Biochemistry
2014
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| _version_ | 1867614196261191680 |
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| access_status_str | Open Access |
| author | Li, Dong-Ping |
| author2 | Parker, Iqbal |
| author_browse | Li, Dong-Ping Parker, Iqbal |
| author_facet | Parker, Iqbal Li, Dong-Ping |
| author_sort | Li, Dong-Ping |
| collection | Thesis |
| description | Includes bibliographical references (leaves 109-130). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3137 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:48:11.930Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3137 Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer Li, Dong-Ping Parker, Iqbal Dandara, Collet Medical Biochemistry Includes bibliographical references (leaves 109-130). Although the incidence and mortality due to the oesophageal squamous cell carcinoma (OSCC) in Black South Africans is extremely high, very little is known about the aetiology and molecular biology of the disease. In order to make a contribution to the understanding to the causes of this disease we investigated the role of the polymorphisms in the genes coding for the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2E1), sulphotransferase 1A1 (SULT1A1), glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds. 2014-07-28T14:55:38Z 2014-07-28T14:55:38Z 2008 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3137 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Li, Dong-Ping Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer |
| thesis_degree_str | Doctoral |
| title | Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer |
| title_full | Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer |
| title_fullStr | Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer |
| title_full_unstemmed | Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer |
| title_short | Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer |
| title_sort | genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/3137 |
| work_keys_str_mv | AT lidongping geneticpolymorphismsinthedrugmetabolizinggenesandtheirrolesinthedevelopmentofoesophagealcancer |