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The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
Bibliography leaves 70-97.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Medical Biochemistry
2014
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| _version_ | 1867613248977633280 |
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| access_status_str | Open Access |
| author | Ndlovu, Matladi N |
| author2 | Parker, M Iqbal |
| author_browse | Ndlovu, Matladi N Parker, M Iqbal |
| author_facet | Parker, M Iqbal Ndlovu, Matladi N |
| author_sort | Ndlovu, Matladi N |
| collection | Thesis |
| description | Bibliography leaves 70-97. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3144 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:08.525Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3144 The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene Ndlovu, Matladi N Parker, M Iqbal Medical Biochemistry Bibliography leaves 70-97. Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated with transcriptional activity and plays a critical role in differential gene expression. 2014-07-28T14:55:50Z 2014-07-28T14:55:50Z 2002 Master Thesis Masters MSc http://hdl.handle.net/11427/3144 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Ndlovu, Matladi N The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
| thesis_degree_str | Master's |
| title | The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
| title_full | The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
| title_fullStr | The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
| title_full_unstemmed | The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
| title_short | The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
| title_sort | role of dna methylation in transcriptional regulation of the human type 1 alpha 2 collagen col1a2 gene |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/3144 |
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