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New precious metal compounds in cancer therapy
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Medical Biochemistry
2014
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| _version_ | 1867614293301657600 |
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| access_status_str | Open Access |
| author | Peters, Dean Douglas |
| author2 | Hendricks, T |
| author_browse | Hendricks, T Peters, Dean Douglas |
| author_facet | Hendricks, T Peters, Dean Douglas |
| author_sort | Peters, Dean Douglas |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3146 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:49:44.475Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3146 New precious metal compounds in cancer therapy Peters, Dean Douglas Hendricks, T Moss, R Medicine Includes abstract. Includes bibliographical references (leaves 139-160). Cisplatin is one of the most effective cancer medications currently available. However, it is seriously limited by patient toxicity and drug resistance. As such, there is a real need for altemative treatments. Some compounds of gold(l) have been found to be biologically active in various contexts, including in killing cancer cells. The metal centres gold(lIl) and rhodium(lI) are isoelectronic to the platinum(ll) centre in cisplatin, and some of their compounds have been shown to have biological activity. The aims of this work were to prepare pyridinecontaining complexes of the three metal centres gold(I), gold(llI) and rhodium(I), and assess these complexes for in vitro anti-cancer activity. Phenyl pyridine and ferrocenylpyridine complexation was achieved with all three metal centres described above. With gold(I), either a chloride or pentafluorophenyl counter-anion was used. The rhodium(l) complexes contained 1,5-cyclooctadiene moieties linked to the metal centre via diene complexation, and a chloride counter-anion. Phenylpyridine complexes of gold(lIl) were achieved via standard reaction with tetrachloroaurate anion. However, the analogous ferrocenylpyridine complexes display unusually low stability and other unexpected physical properties, and are believed to be highly novel chlorobridged gold dimers. The 4-phenylpyridine complex of rhodium(l) was initially found to be active against cancer cells in vitro. It was, however, demonstrated that this activity was actually due to the breakdown product of this compound in DMSO. It was found that this breakdown product interacts with DNA, implying a similar mechanism of action to cisplatin. This is supported by the fact that a cisplatin-resistant cell line displays hjgh cross-resistance against this product. (4-Phenylpyridine)gold(l) (pentafluorophenyl) was also found to be extremely active against cell lines in vitro 2014-07-28T14:55:53Z 2014-07-28T14:55:53Z 2008 Master Thesis Masters MSc http://hdl.handle.net/11427/3146 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Peters, Dean Douglas New precious metal compounds in cancer therapy |
| thesis_degree_str | Master's |
| title | New precious metal compounds in cancer therapy |
| title_full | New precious metal compounds in cancer therapy |
| title_fullStr | New precious metal compounds in cancer therapy |
| title_full_unstemmed | New precious metal compounds in cancer therapy |
| title_short | New precious metal compounds in cancer therapy |
| title_sort | new precious metal compounds in cancer therapy |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3146 |
| work_keys_str_mv | AT petersdeandouglas newpreciousmetalcompoundsincancertherapy |