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The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer
Includes bibliographical references (leaves 74-83).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Medical Biochemistry
2014
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| _version_ | 1867614209407188992 |
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| access_status_str | Open Access |
| author | Ross-Innes, Caryn Sarah |
| author2 | Parker, M Iqbal |
| author_browse | Parker, M Iqbal Ross-Innes, Caryn Sarah |
| author_facet | Parker, M Iqbal Ross-Innes, Caryn Sarah |
| author_sort | Ross-Innes, Caryn Sarah |
| collection | Thesis |
| description | Includes bibliographical references (leaves 74-83). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3148 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:48:24.466Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3148 The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer Ross-Innes, Caryn Sarah Parker, M Iqbal Dandara, Collet Medical Biochemistry Includes bibliographical references (leaves 74-83). Oesophageal squamous cell carcinoma (OSCC) is a major cancer in South Africa, affecting mainly black males. Several risk factors for OSCC have been reported but this study focuses on the role of human papilloma virus (HPV) in the development of OSCC. HPV is a well-known risk factor for cervical cancer resulting in its classification into low- and high-risk HPV types. The role of the different HPV types in OSCC development is not known, but in cervical cancer the critical HPV transforming gene has been shown to be E6. In this project, the effects of HPV11 E6, a low-risk type, and HPV18 E6, a high-risk type, were investigated by transfecting HPV-negative cell lines (EPC2-hTERT, MCF12A and Rat1) with HPV11 and HPV18 E6. 2014-07-28T14:55:56Z 2014-07-28T14:55:56Z 2007 Master Thesis Masters MSc http://hdl.handle.net/11427/3148 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Ross-Innes, Caryn Sarah The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer |
| thesis_degree_str | Master's |
| title | The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer |
| title_full | The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer |
| title_fullStr | The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer |
| title_full_unstemmed | The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer |
| title_short | The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer |
| title_sort | role of human papillomavirus hpv e6 proteins as a risk factor for oesophageal cancer |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/3148 |
| work_keys_str_mv | AT rossinnescarynsarah theroleofhumanpapillomavirushpve6proteinsasariskfactorforoesophagealcancer AT rossinnescarynsarah roleofhumanpapillomavirushpve6proteinsasariskfactorforoesophagealcancer |