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Identification of signalling pathways regulating TBX2 gene expression and its target genes
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Biochemistry
2014
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| _version_ | 1867613203568001024 |
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| access_status_str | Open Access |
| author | Teng, Huajian |
| author2 | Prince, Sharon |
| author_browse | Prince, Sharon Teng, Huajian |
| author_facet | Prince, Sharon Teng, Huajian |
| author_sort | Teng, Huajian |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3151 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:24.523Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3151 Identification of signalling pathways regulating TBX2 gene expression and its target genes Teng, Huajian Prince, Sharon Parker, M I Medical Biochemistry Includes abstract. Includes bibliographical references (leaves 83-97). Members of the T-box family of transcription factors provide an important link between development and cancer. T-box factors play critical roles in embryonic development and results from recent studies suggest that they function in controlling cell cycle progression and also in the genesis of cancer. Importantly, the T-box factors Tbx2 and Tbx3 are overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver and bladder cancers and can suppress senescence, a cellular process which serves as a barrier to cancer development. However, the precise role of most T-box factors is poorly defined, in part, because their target genes are still poorly characterised and very little is known of the signalling pathways that regulate their expression and activity. The broad aim of this study was therefore to contribute towards the identification of Tbx2 target genes as well as to identify signalling pathways that regulate TBX2 expression. The specific aims were thus to (1) investigate the regulation of type1 collagen gene expression by Tbx2; (2) clone the human TBX2 regulatory region and to identify cis-acting elements involved in the basal transcription of the TBX2 gene and (3) investigate the regulation of TBX2 gene expression by signalling pathways. 2014-07-28T14:56:00Z 2014-07-28T14:56:00Z 2008 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3151 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Teng, Huajian Identification of signalling pathways regulating TBX2 gene expression and its target genes |
| thesis_degree_str | Doctoral |
| title | Identification of signalling pathways regulating TBX2 gene expression and its target genes |
| title_full | Identification of signalling pathways regulating TBX2 gene expression and its target genes |
| title_fullStr | Identification of signalling pathways regulating TBX2 gene expression and its target genes |
| title_full_unstemmed | Identification of signalling pathways regulating TBX2 gene expression and its target genes |
| title_short | Identification of signalling pathways regulating TBX2 gene expression and its target genes |
| title_sort | identification of signalling pathways regulating tbx2 gene expression and its target genes |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/3151 |
| work_keys_str_mv | AT tenghuajian identificationofsignallingpathwaysregulatingtbx2geneexpressionanditstargetgenes |