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Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis
Ulcerative colitis (UC) is a heterogeneous inflammatory bowel disease (IBD) associated with chronic inflammation of the gastrointestinal tract. Characterized by genetic and immunological abnormalities, UC has overly aggressive T-cell responses to commensal bacteria eventually leading to disease path...
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| Format: | Thesis |
| Language: | English |
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Department of Clinical Laboratory Sciences
2014
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| _version_ | 1867613307910750208 |
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| access_status_str | Open Access |
| author | Hoving, J Claire |
| author2 | Brombacher, Frank |
| author_browse | Brombacher, Frank Hoving, J Claire |
| author_facet | Brombacher, Frank Hoving, J Claire |
| author_sort | Hoving, J Claire |
| collection | Thesis |
| description | Ulcerative colitis (UC) is a heterogeneous inflammatory bowel disease (IBD) associated with chronic inflammation of the gastrointestinal tract. Characterized by genetic and immunological abnormalities, UC has overly aggressive T-cell responses to commensal bacteria eventually leading to disease pathology. UC is distinguished from Crohn's disease, another form of IBD, in that it is driven by a T helper type 2 (Th2) immune response. Oxazolone-induced colitis is a mouse model resembling UC presenting with inflammation limited to the distal colon and mixed neutrophil/lymphocyte infiltration in the superficial layer of the mucosa. The Th2 cytokines interleukin (IL)-4 and IL-13 are associated with the onset of oxazolone colitis and both signal through a common IL-4 receptor-alpha chain (IL-4R +-). Neutralizing these cytokines prevents or ameliorates disease significantly, while neutralizing IL-12 exacerbates disease symptoms. As many aspects of the mechanisms involving Th2 cytokines in colitis remain undefined, the aim of this study was to investigate the role of IL-4 and IL-13 and the receptors through which they signal in oxazolone-induced colitis. Previous studies have highlighted a role for IL-4 and IL-13 in mediating oxazolone colitis. We show that while IL-13-deficient BALB/c mice were protected from disease onset, IL-4R +- deficient BALB/c mice developed exacerbated disease symptoms. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3164 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:03.682Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Clinical Laboratory Sciences |
| publisherStr | Department of Clinical Laboratory Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3164 Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis Hoving, J Claire Brombacher, Frank Immunology Ulcerative colitis (UC) is a heterogeneous inflammatory bowel disease (IBD) associated with chronic inflammation of the gastrointestinal tract. Characterized by genetic and immunological abnormalities, UC has overly aggressive T-cell responses to commensal bacteria eventually leading to disease pathology. UC is distinguished from Crohn's disease, another form of IBD, in that it is driven by a T helper type 2 (Th2) immune response. Oxazolone-induced colitis is a mouse model resembling UC presenting with inflammation limited to the distal colon and mixed neutrophil/lymphocyte infiltration in the superficial layer of the mucosa. The Th2 cytokines interleukin (IL)-4 and IL-13 are associated with the onset of oxazolone colitis and both signal through a common IL-4 receptor-alpha chain (IL-4R +-). Neutralizing these cytokines prevents or ameliorates disease significantly, while neutralizing IL-12 exacerbates disease symptoms. As many aspects of the mechanisms involving Th2 cytokines in colitis remain undefined, the aim of this study was to investigate the role of IL-4 and IL-13 and the receptors through which they signal in oxazolone-induced colitis. Previous studies have highlighted a role for IL-4 and IL-13 in mediating oxazolone colitis. We show that while IL-13-deficient BALB/c mice were protected from disease onset, IL-4R +- deficient BALB/c mice developed exacerbated disease symptoms. 2014-07-28T14:57:25Z 2014-07-28T14:57:25Z 2010 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3164 eng application/pdf Department of Clinical Laboratory Sciences Faculty of Health Sciences University of Cape Town |
| spellingShingle | Immunology Hoving, J Claire Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis |
| thesis_degree_str | Doctoral |
| title | Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis |
| title_full | Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis |
| title_fullStr | Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis |
| title_full_unstemmed | Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis |
| title_short | Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis |
| title_sort | investigating the role of il 4 il 13 and their receptors in ulcerative colitis |
| topic | Immunology |
| url | http://hdl.handle.net/11427/3164 |
| work_keys_str_mv | AT hovingjclaire investigatingtheroleofil4il13andtheirreceptorsinulcerativecolitis |