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Cardiovascular magnetic resonance and right ventricular angiography in assessment of right ventricular volumes, function and wall motion abnormalities in arrhythmogenic right ventricular cardiomyopathy: a comparative study
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterised by structural changes to mostly the right ventricle (RV) that predisposes to ventricular arrhythmias heart failure and sudden cardiac death. ARVC is diagnosed using the 2010 Task Force Cri...
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2020
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| _version_ | 1867613469315956736 |
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| access_status_str | Open Access |
| author | Huang, Hsin-Chi |
| author2 | Ntusi, Ntobeko A B |
| author_browse | Huang, Hsin-Chi Ntusi, Ntobeko A B |
| author_facet | Ntusi, Ntobeko A B Huang, Hsin-Chi |
| author_sort | Huang, Hsin-Chi |
| collection | Thesis |
| description | Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterised by structural changes to mostly the right ventricle (RV) that predisposes to ventricular arrhythmias heart failure and sudden cardiac death. ARVC is diagnosed using the 2010 Task Force Criteria which include RV angiography (RVA) and cardiovascular magnetic resonance (CMR). There has been a dearth of studies to document the comparison of the performance of CMR and RVA, and none undertaken in Africa. The aim of this study was to compare CMR and RVA in the assessment of ARVC in the South African ARVC registry. Methods: The study is a retrospective analysis of definite, possible and borderline ARVC cases from the South African ARVC registry and the African Cardiomyopathy and Myocarditis Registry Program (IMHOTEP) that have both CMR and RVA data. RV end-systolic and diastolic volumes, RV ejection fractions and the presence of absence of structural abnormalities derived from RVA and CMR are compared. Sensitivity of CMR and RVA for the diagnosis of definite, possible and borderline ARVC was also calculated. Results: A total of 11 patients out of 62 from the registry met the inclusion criteria. The Spearman’s coefficient for RV end-systolic volume was 0.48 (p=0.12). The Spearman’s coefficient for RV enddiastolic volume was 0.28 (p=0.4). The Spearman’s coefficient for RV ejection fraction was 0.06 (p=0.85). CMR detected regional wall abnormalities in 4 out of 11 patients while RVA did not detect any regional wall abnormalities. Sensitivity of CMR and RVA for the diagnosis of definite, possible and borderline ARVC was 48% and 55%, respectively. Conclusions: We show that South African ARVC patients had poor correlation between CMR and RVA parameters, and CMR was also more likely to reveal RV free wall regional wall motion abnormalities. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/31643 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:36:38.661Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/31643 Cardiovascular magnetic resonance and right ventricular angiography in assessment of right ventricular volumes, function and wall motion abnormalities in arrhythmogenic right ventricular cardiomyopathy: a comparative study Huang, Hsin-Chi Ntusi, Ntobeko A B Medicine Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterised by structural changes to mostly the right ventricle (RV) that predisposes to ventricular arrhythmias heart failure and sudden cardiac death. ARVC is diagnosed using the 2010 Task Force Criteria which include RV angiography (RVA) and cardiovascular magnetic resonance (CMR). There has been a dearth of studies to document the comparison of the performance of CMR and RVA, and none undertaken in Africa. The aim of this study was to compare CMR and RVA in the assessment of ARVC in the South African ARVC registry. Methods: The study is a retrospective analysis of definite, possible and borderline ARVC cases from the South African ARVC registry and the African Cardiomyopathy and Myocarditis Registry Program (IMHOTEP) that have both CMR and RVA data. RV end-systolic and diastolic volumes, RV ejection fractions and the presence of absence of structural abnormalities derived from RVA and CMR are compared. Sensitivity of CMR and RVA for the diagnosis of definite, possible and borderline ARVC was also calculated. Results: A total of 11 patients out of 62 from the registry met the inclusion criteria. The Spearman’s coefficient for RV end-systolic volume was 0.48 (p=0.12). The Spearman’s coefficient for RV enddiastolic volume was 0.28 (p=0.4). The Spearman’s coefficient for RV ejection fraction was 0.06 (p=0.85). CMR detected regional wall abnormalities in 4 out of 11 patients while RVA did not detect any regional wall abnormalities. Sensitivity of CMR and RVA for the diagnosis of definite, possible and borderline ARVC was 48% and 55%, respectively. Conclusions: We show that South African ARVC patients had poor correlation between CMR and RVA parameters, and CMR was also more likely to reveal RV free wall regional wall motion abnormalities. 2020-04-20T18:14:23Z 2020-04-20T18:14:23Z 2019 2020-04-20T17:56:34Z Master Thesis Masters MMed https://hdl.handle.net/11427/31643 eng application/pdf Department of Medicine Faculty of Health Sciences |
| spellingShingle | Medicine Huang, Hsin-Chi Cardiovascular magnetic resonance and right ventricular angiography in assessment of right ventricular volumes, function and wall motion abnormalities in arrhythmogenic right ventricular cardiomyopathy: a comparative study |
| thesis_degree_str | Master's |
| title | Cardiovascular magnetic resonance and right ventricular angiography in assessment of right ventricular volumes, function and wall motion abnormalities in arrhythmogenic right ventricular cardiomyopathy: a comparative study |
| title_full | Cardiovascular magnetic resonance and right ventricular angiography in assessment of right ventricular volumes, function and wall motion abnormalities in arrhythmogenic right ventricular cardiomyopathy: a comparative study |
| title_fullStr | Cardiovascular magnetic resonance and right ventricular angiography in assessment of right ventricular volumes, function and wall motion abnormalities in arrhythmogenic right ventricular cardiomyopathy: a comparative study |
| title_full_unstemmed | Cardiovascular magnetic resonance and right ventricular angiography in assessment of right ventricular volumes, function and wall motion abnormalities in arrhythmogenic right ventricular cardiomyopathy: a comparative study |
| title_short | Cardiovascular magnetic resonance and right ventricular angiography in assessment of right ventricular volumes, function and wall motion abnormalities in arrhythmogenic right ventricular cardiomyopathy: a comparative study |
| title_sort | cardiovascular magnetic resonance and right ventricular angiography in assessment of right ventricular volumes function and wall motion abnormalities in arrhythmogenic right ventricular cardiomyopathy a comparative study |
| topic | Medicine |
| url | https://hdl.handle.net/11427/31643 |
| work_keys_str_mv | AT huanghsinchi cardiovascularmagneticresonanceandrightventricularangiographyinassessmentofrightventricularvolumesfunctionandwallmotionabnormalitiesinarrhythmogenicrightventricularcardiomyopathyacomparativestudy |