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Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Clinical Laboratory Sciences
2014
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| _version_ | 1867613233502748672 |
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| access_status_str | Open Access |
| author | Ndlovu, H Hlumani |
| author2 | Brombacher, Frank |
| author_browse | Brombacher, Frank Ndlovu, H Hlumani |
| author_facet | Brombacher, Frank Ndlovu, H Hlumani |
| author_sort | Ndlovu, H Hlumani |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3176 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:52.713Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Clinical Laboratory Sciences |
| publisherStr | Department of Clinical Laboratory Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3176 Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice Ndlovu, H Hlumani Brombacher, Frank Horsnell, William Clinical Laboratory Sciences Includes abstract. Includes bibliographical references. The aim of this study was to evaluate the importance of CD28 in initiating protective Th2 immunity against both primary and secondary infections with N. brasiliensis. Our findings demonstrate that CD28 is required for initiation of protective Th2 immunity against primary infection with N. brasiliensis. Furthermore, the absence of CD28 impairs development of memory CD4⁺ T cell responses resulting in failure to clear adult N. brasiliensis worms during secondary infection. Failure to resolve infection was associated with reduced production of Th2 cytokines particularly IL-13 and IL-4, abrogated humoral immunity and failure to expand CXCR5⁺ TFH cells. 2014-07-28T14:57:45Z 2014-07-28T14:57:45Z 2013 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3176 eng application/pdf Department of Clinical Laboratory Sciences Faculty of Health Sciences University of Cape Town |
| spellingShingle | Clinical Laboratory Sciences Ndlovu, H Hlumani Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice |
| thesis_degree_str | Doctoral |
| title | Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice |
| title_full | Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice |
| title_fullStr | Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice |
| title_full_unstemmed | Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice |
| title_short | Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice |
| title_sort | investigating the role of cd28 costimulation and il 4 il 13 responsive myeloid and lymphoid cells during helminth infections in mice |
| topic | Clinical Laboratory Sciences |
| url | http://hdl.handle.net/11427/3176 |
| work_keys_str_mv | AT ndlovuhhlumani investigatingtheroleofcd28costimulationandil4il13responsivemyeloidandlymphoidcellsduringhelminthinfectionsinmice |