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Mechanisms of activation of glycogenolysis during development of malignant hyperthermia in swine
The syndrome of Malignant Hyperpyrexia in man follows administration of certain general anaesthetic agents, and, although rare, is fatal in 70% of cases (EDITORIAL, 1968). Following exposure to the anaesthetic, there is, in most instances of susceptible individuals, a rapid rise in body temperature...
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| Format: | Thesis |
| Language: | English |
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Department of Anaesthesia and Perioperative Medicine
2020
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| _version_ | 1867613157551243264 |
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| access_status_str | Open Access |
| author | Conradie, Paulina Jacoba |
| author2 | Berman, M |
| author_browse | Berman, M Conradie, Paulina Jacoba |
| author_facet | Berman, M Conradie, Paulina Jacoba |
| author_sort | Conradie, Paulina Jacoba |
| collection | Thesis |
| description | The syndrome of Malignant Hyperpyrexia in man follows administration of certain general anaesthetic agents, and, although rare, is fatal in 70% of cases (EDITORIAL,
1968). Following exposure to the anaesthetic, there is, in most instances of susceptible individuals, a rapid rise in body temperature, usually within a period of 10 minutes, often accompanied by muscular rigidity of the limbs~ Sometimes hyperthermia has.been delayed for hours and muscular rigidity not pronounced. The temperature reached maybe 43°C (115°F) or even somewhat above this. Halothane, CF3CHBrCl, a ha../o/~nated hydrocarbon, is thought to be responsible for most cases(WILSON, NICHOLS, DENT and ALLEN, 1966). Succinyl choline lfH2COOCH2CH2*(cH3 )~ 201_~H2COOCH2CH2~(cH3 )3 a skeletal muscle relaxant employed during anaesthesia, has also been implicated (BRITT and KALOW, 1970; HARRISON, 1971). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/31878 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:41.113Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Anaesthesia and Perioperative Medicine |
| publisherStr | Department of Anaesthesia and Perioperative Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/31878 Mechanisms of activation of glycogenolysis during development of malignant hyperthermia in swine Conradie, Paulina Jacoba Berman, M Glycolysis anaesthetic malignant hyperpyrexia anaesthesia The syndrome of Malignant Hyperpyrexia in man follows administration of certain general anaesthetic agents, and, although rare, is fatal in 70% of cases (EDITORIAL, 1968). Following exposure to the anaesthetic, there is, in most instances of susceptible individuals, a rapid rise in body temperature, usually within a period of 10 minutes, often accompanied by muscular rigidity of the limbs~ Sometimes hyperthermia has.been delayed for hours and muscular rigidity not pronounced. The temperature reached maybe 43°C (115°F) or even somewhat above this. Halothane, CF3CHBrCl, a ha../o/~nated hydrocarbon, is thought to be responsible for most cases(WILSON, NICHOLS, DENT and ALLEN, 1966). Succinyl choline lfH2COOCH2CH2*(cH3 )~ 201_~H2COOCH2CH2~(cH3 )3 a skeletal muscle relaxant employed during anaesthesia, has also been implicated (BRITT and KALOW, 1970; HARRISON, 1971). 2020-05-14T12:18:40Z 2020-05-14T12:18:40Z 1971 2020-04-06T11:55:56Z Master Thesis Masters https://hdl.handle.net/11427/31878 eng application/pdf Department of Anaesthesia and Perioperative Medicine Faculty of Health Sciences |
| spellingShingle | Glycolysis anaesthetic malignant hyperpyrexia anaesthesia Conradie, Paulina Jacoba Mechanisms of activation of glycogenolysis during development of malignant hyperthermia in swine |
| thesis_degree_str | Master's |
| title | Mechanisms of activation of glycogenolysis during development of malignant hyperthermia in swine |
| title_full | Mechanisms of activation of glycogenolysis during development of malignant hyperthermia in swine |
| title_fullStr | Mechanisms of activation of glycogenolysis during development of malignant hyperthermia in swine |
| title_full_unstemmed | Mechanisms of activation of glycogenolysis during development of malignant hyperthermia in swine |
| title_short | Mechanisms of activation of glycogenolysis during development of malignant hyperthermia in swine |
| title_sort | mechanisms of activation of glycogenolysis during development of malignant hyperthermia in swine |
| topic | Glycolysis anaesthetic malignant hyperpyrexia anaesthesia |
| url | https://hdl.handle.net/11427/31878 |
| work_keys_str_mv | AT conradiepaulinajacoba mechanismsofactivationofglycogenolysisduringdevelopmentofmalignanthyperthermiainswine |