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Investigations of the Genetic aspects of the mixed Lymphocyte culture reaction in Southern Africa

The genetic relationship between the serologically detectable antigens of the HLA-A and B loci and the mixed lymphocyte culture (MLC) reaction is of utmost importance in the understanding of histocompatibility. From the literature it appeared that neither the HLA-A, B genotype nor the MLC reaction...

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Main Author: du Toit, Ernette D
Format: Thesis
Language:English
Published: Adolescent Health Research Institute 2020
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access_status_str Open Access
author du Toit, Ernette D
author_browse du Toit, Ernette D
author_facet du Toit, Ernette D
author_sort du Toit, Ernette D
collection Thesis
description The genetic relationship between the serologically detectable antigens of the HLA-A and B loci and the mixed lymphocyte culture (MLC) reaction is of utmost importance in the understanding of histocompatibility. From the literature it appeared that neither the HLA-A, B genotype nor the MLC reaction is the complete answer to donorrecipient selection in organ transplantation. This study was therefore initiated in June 1971 in an attempt to clarify the problem. It is inherent in a project of this nature that much time is spent in collecting samples from donors in diverse areas. Most experiments had to be repeated two or three times, therefore some of the problems we set out to resolve were clarified by other workers before we were able to complete our investigations.
format Thesis
id oai:open.uct.ac.za:11427/31922
institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:48:00.715Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2020
publishDateRange 2020
publishDateSort 2020
publisher Adolescent Health Research Institute
publisherStr Adolescent Health Research Institute
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/31922 Investigations of the Genetic aspects of the mixed Lymphocyte culture reaction in Southern Africa du Toit, Ernette D Lymphocyte culture Leukocyte antigens The genetic relationship between the serologically detectable antigens of the HLA-A and B loci and the mixed lymphocyte culture (MLC) reaction is of utmost importance in the understanding of histocompatibility. From the literature it appeared that neither the HLA-A, B genotype nor the MLC reaction is the complete answer to donorrecipient selection in organ transplantation. This study was therefore initiated in June 1971 in an attempt to clarify the problem. It is inherent in a project of this nature that much time is spent in collecting samples from donors in diverse areas. Most experiments had to be repeated two or three times, therefore some of the problems we set out to resolve were clarified by other workers before we were able to complete our investigations. 2020-05-19T11:20:19Z 2020-05-19T11:20:19Z 1978 2020-04-16T07:14:35Z Doctoral Thesis Doctoral https://hdl.handle.net/11427/31922 eng application/pdf Adolescent Health Research Institute Faculty of Health Sciences
spellingShingle Lymphocyte culture
Leukocyte antigens
du Toit, Ernette D
Investigations of the Genetic aspects of the mixed Lymphocyte culture reaction in Southern Africa
thesis_degree_str Doctoral
title Investigations of the Genetic aspects of the mixed Lymphocyte culture reaction in Southern Africa
title_full Investigations of the Genetic aspects of the mixed Lymphocyte culture reaction in Southern Africa
title_fullStr Investigations of the Genetic aspects of the mixed Lymphocyte culture reaction in Southern Africa
title_full_unstemmed Investigations of the Genetic aspects of the mixed Lymphocyte culture reaction in Southern Africa
title_short Investigations of the Genetic aspects of the mixed Lymphocyte culture reaction in Southern Africa
title_sort investigations of the genetic aspects of the mixed lymphocyte culture reaction in southern africa
topic Lymphocyte culture
Leukocyte antigens
url https://hdl.handle.net/11427/31922
work_keys_str_mv AT dutoiternetted investigationsofthegeneticaspectsofthemixedlymphocyteculturereactioninsouthernafrica