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Genetic risk factors for anterior cruciate ligament ruptures
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Human Biology
2014
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| _version_ | 1867613226111336449 |
|---|---|
| access_status_str | Open Access |
| author | Posthumus, Michael |
| author2 | Collins, Malcolm |
| author_browse | Collins, Malcolm Posthumus, Michael |
| author_facet | Collins, Malcolm Posthumus, Michael |
| author_sort | Posthumus, Michael |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3195 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:46.693Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3195 Genetic risk factors for anterior cruciate ligament ruptures Posthumus, Michael Collins, Malcolm Schwellnus, Martin Human Biology Includes abstract. Includes bibliographical references (p. 197-215). The primary aim of this thesis was to identify candidate genes that may be associated with ACL ruptures, and then use a genetic association approach following a case-control study design to identify specific sequence variants (single nucleotide polymorphisms, SNPs) within these candidate genes which may predispose individuals to ACL ruptures. Candidate genes (COL1A1, COL5A1 and COL12A1) were selected based on the biological function of their encoded proteins (type I, type V and type XII collagen respectively) within the basic structural and functional unit of ligaments, namely the collagen microfibril. 2014-07-28T18:14:20Z 2014-07-28T18:14:20Z 2009 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3195 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Human Biology Posthumus, Michael Genetic risk factors for anterior cruciate ligament ruptures |
| thesis_degree_str | Doctoral |
| title | Genetic risk factors for anterior cruciate ligament ruptures |
| title_full | Genetic risk factors for anterior cruciate ligament ruptures |
| title_fullStr | Genetic risk factors for anterior cruciate ligament ruptures |
| title_full_unstemmed | Genetic risk factors for anterior cruciate ligament ruptures |
| title_short | Genetic risk factors for anterior cruciate ligament ruptures |
| title_sort | genetic risk factors for anterior cruciate ligament ruptures |
| topic | Human Biology |
| url | http://hdl.handle.net/11427/3195 |
| work_keys_str_mv | AT posthumusmichael geneticriskfactorsforanteriorcruciateligamentruptures |