Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster
Salley in 1954, (122) was the first worker to use the hamster cheek pouch as a model for experimental carcinogenesis and to produce squamous cell carcinomas in this organ. For a number of reasons, the pouch is most suitable for sequential studies of carcinogenesis, and these include the fact that it...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2020
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613190212288512 |
|---|---|
| access_status_str | Open Access |
| author | Polliack, Aaron |
| author2 | Levij, I S |
| author_browse | Levij, I S Polliack, Aaron |
| author_facet | Levij, I S Polliack, Aaron |
| author_sort | Polliack, Aaron |
| collection | Thesis |
| description | Salley in 1954, (122) was the first worker to use the hamster cheek pouch as a model for experimental carcinogenesis and to produce squamous cell carcinomas in this organ. For a number of reasons, the pouch is most suitable for sequential studies of carcinogenesis, and these include the fact that it is easily accessible and can be everted simply, facilitating macroscopic examination. Furthermore, its anatomic situation makes it a simple model for topical application of any carcinogen. Each animal has two pouches, thus providing its own control. In addition, the pouch serves as a storehouse and is lined only by stratified squamous epithelium with no glands or hair follicles in its wall, thus rendering it less susceptible to cyclic changes than more complex tissues, in which accessory structures are present. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/31963 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:12.136Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/31963 The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster Polliack, Aaron Levij, I S Neoplasms Chemically induced Salley in 1954, (122) was the first worker to use the hamster cheek pouch as a model for experimental carcinogenesis and to produce squamous cell carcinomas in this organ. For a number of reasons, the pouch is most suitable for sequential studies of carcinogenesis, and these include the fact that it is easily accessible and can be everted simply, facilitating macroscopic examination. Furthermore, its anatomic situation makes it a simple model for topical application of any carcinogen. Each animal has two pouches, thus providing its own control. In addition, the pouch serves as a storehouse and is lined only by stratified squamous epithelium with no glands or hair follicles in its wall, thus rendering it less susceptible to cyclic changes than more complex tissues, in which accessory structures are present. 2020-05-21T14:46:58Z 2020-05-21T14:46:58Z 1969 2020-04-14T07:58:16Z Doctoral Thesis Doctoral https://hdl.handle.net/11427/31963 eng application/pdf Department of Medicine Faculty of Health Sciences |
| spellingShingle | Neoplasms Chemically induced Polliack, Aaron The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster |
| thesis_degree_str | Doctoral |
| title | The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster |
| title_full | The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster |
| title_fullStr | The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster |
| title_full_unstemmed | The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster |
| title_short | The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster |
| title_sort | co carcinogenic effect of topical vitamin a palmitate on 9 10 dimethyl 1 2 benzathracene dmba induced carcinoma in the buccal pouch of the syrian golden hamster |
| topic | Neoplasms Chemically induced |
| url | https://hdl.handle.net/11427/31963 |
| work_keys_str_mv | AT polliackaaron thecocarcinogeniceffectoftopicalvitaminapalmitateon910dimethyl12benzathracenedmbainducedcarcinomainthebuccalpouchofthesyriangoldenhamster AT polliackaaron cocarcinogeniceffectoftopicalvitaminapalmitateon910dimethyl12benzathracenedmbainducedcarcinomainthebuccalpouchofthesyriangoldenhamster |