Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Protein clearances and renal protein selectivity in the proteinurias of pregnancy
Ever since the association between altJ.Jminuria and eclampsia was noted by Lever in 1843, the kidney has figured in the forefront in the search for aetiological factors. Lever, who was a contemporary of Bright at Guy's Hospital, observed the close similarity in appearance between many of his eclamp...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Obstetrics and Gynaecology
2020
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613183615696896 |
|---|---|
| access_status_str | Open Access |
| author | Simanowitz, Milton David |
| author2 | McClure Brown J C |
| author_browse | McClure Brown J C Simanowitz, Milton David |
| author_facet | McClure Brown J C Simanowitz, Milton David |
| author_sort | Simanowitz, Milton David |
| collection | Thesis |
| description | Ever since the association between altJ.Jminuria and eclampsia was noted by Lever in 1843, the kidney has figured in the forefront in the search for aetiological factors. Lever, who was a contemporary of Bright at Guy's Hospital, observed the close similarity in appearance between many of his eclamptic patients and patients with Bright's disease. Examination of the urine was the logical next step. Having fould albumin in nine out of ten eclamptic patients in whom the urine had been examined, he went on to exanine the urine of fifty "normal 11 controls, and (rather surprisingly, since one would have anticipated a proportion of unrecognised preeclamptic patients amongst these) found albumin to be absent in every case. Lever recognised the "transitory nature 11 of pregnancy proteinuria and concluded that the condition differed from the permanent proteinuria of Bright's disease.In the same month of the same year (1843), Simpson made a similar observation in Edinburgh regarding proteinuria and eclampsia. Whilst also recognising that albuminuria disappeared in those patients who survived, he never theless attributed the syndrome of albuminuria and convulsions to underlying Bright's disease. This was a view that persisted for some time despite its obvious inconsistencies. Carl Braun of Vienna endorsed this concept and the chapter dealing with albuminuria and eclampsia in his "Lerbuch" was translated and run as a series of articles in the Edinburgh Medical Journal (1856 57). In this work, Braun states firmly that eclampsia is a direct result of the uraemia resulting from poorly functioning kidneys. The kidney featured prominently in many subsequent theories on aetiology but the idea of primary renal disease being the origin of the process leading to eclampsia was shortlived. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/31970 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:06.010Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Obstetrics and Gynaecology |
| publisherStr | Department of Obstetrics and Gynaecology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/31970 Protein clearances and renal protein selectivity in the proteinurias of pregnancy Simanowitz, Milton David McClure Brown J C Proteinuria pregnancy Pregnancy toxemias Ever since the association between altJ.Jminuria and eclampsia was noted by Lever in 1843, the kidney has figured in the forefront in the search for aetiological factors. Lever, who was a contemporary of Bright at Guy's Hospital, observed the close similarity in appearance between many of his eclamptic patients and patients with Bright's disease. Examination of the urine was the logical next step. Having fould albumin in nine out of ten eclamptic patients in whom the urine had been examined, he went on to exanine the urine of fifty "normal 11 controls, and (rather surprisingly, since one would have anticipated a proportion of unrecognised preeclamptic patients amongst these) found albumin to be absent in every case. Lever recognised the "transitory nature 11 of pregnancy proteinuria and concluded that the condition differed from the permanent proteinuria of Bright's disease.In the same month of the same year (1843), Simpson made a similar observation in Edinburgh regarding proteinuria and eclampsia. Whilst also recognising that albuminuria disappeared in those patients who survived, he never theless attributed the syndrome of albuminuria and convulsions to underlying Bright's disease. This was a view that persisted for some time despite its obvious inconsistencies. Carl Braun of Vienna endorsed this concept and the chapter dealing with albuminuria and eclampsia in his "Lerbuch" was translated and run as a series of articles in the Edinburgh Medical Journal (1856 57). In this work, Braun states firmly that eclampsia is a direct result of the uraemia resulting from poorly functioning kidneys. The kidney featured prominently in many subsequent theories on aetiology but the idea of primary renal disease being the origin of the process leading to eclampsia was shortlived. 2020-05-22T11:52:40Z 2020-05-22T11:52:40Z 1971 2020-04-14T09:43:27Z Doctoral Thesis Doctoral https://hdl.handle.net/11427/31970 eng application/pdf Department of Obstetrics and Gynaecology Faculty of Health Sciences |
| spellingShingle | Proteinuria pregnancy Pregnancy toxemias Simanowitz, Milton David Protein clearances and renal protein selectivity in the proteinurias of pregnancy |
| thesis_degree_str | Doctoral |
| title | Protein clearances and renal protein selectivity in the proteinurias of pregnancy |
| title_full | Protein clearances and renal protein selectivity in the proteinurias of pregnancy |
| title_fullStr | Protein clearances and renal protein selectivity in the proteinurias of pregnancy |
| title_full_unstemmed | Protein clearances and renal protein selectivity in the proteinurias of pregnancy |
| title_short | Protein clearances and renal protein selectivity in the proteinurias of pregnancy |
| title_sort | protein clearances and renal protein selectivity in the proteinurias of pregnancy |
| topic | Proteinuria pregnancy Pregnancy toxemias |
| url | https://hdl.handle.net/11427/31970 |
| work_keys_str_mv | AT simanowitzmiltondavid proteinclearancesandrenalproteinselectivityintheproteinuriasofpregnancy |