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The distribution of plasminogen activator in the male genital tract
The blood of man is rich in plasminogen, the inactive precursor of plasmin, a protease (Astrup, 1956a); the most characteristic action of plasmin is the digestion of fibrin, i.e. fibrinolysis. Many tissues, including the prostate (Rasmussen and Albrechtsen, 1960a), contain substances which can activ...
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| Format: | Thesis |
| Language: | English |
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Department of Surgery
2020
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| _version_ | 1867613217803468800 |
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| access_status_str | Open Access |
| author | Kester, Ralph Charles |
| author2 | Toadd, Alistair S |
| author_browse | Kester, Ralph Charles Toadd, Alistair S |
| author_facet | Toadd, Alistair S Kester, Ralph Charles |
| author_sort | Kester, Ralph Charles |
| collection | Thesis |
| description | The blood of man is rich in plasminogen, the inactive precursor of plasmin, a protease (Astrup, 1956a); the most characteristic action of plasmin is the digestion of fibrin, i.e. fibrinolysis. Many tissues, including the prostate (Rasmussen and Albrechtsen, 1960a), contain substances which can activate plasminogen, and thus initiate fibrinolysis, and it has been assumed that both the excessive fibrinolysis seen in the blood of some patients with prostatic disease (Tagnon, Whitmore, Schulman and Kravitz, 1953a), and in prostatic surgery (Lombardo, 1957), is due to the release of this activator into the blood stream (Fearnley, 1965). Human semen contains a substance which can activate the blood fibrinolytic system (von Kaulla and Shettles, 1953). Indeed, when human seminal fluid is ejaculated, it undergoes a process resembling the clotting and fibrinolysis of the blood, by coagulating then liquefying spontaneously. The coagulum is formed when a fibrinogenlike protein secreted by the seminal vesicles is acted upon by a clotting enzyme from the prostate (Mann, 1964). Coagulation is followed within about 20 minutes by liquefactionliquefaction of the clots by an enzyme assumed to come from the prostate (Huggins and Neal, 1942). This enzyme resembles plasmin in that it is a protease acting on a fibrin-like substrate, and that it is derived from an
inactive precursor. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/32014 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:38.580Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Surgery |
| publisherStr | Department of Surgery |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/32014 The distribution of plasminogen activator in the male genital tract Kester, Ralph Charles Toadd, Alistair S Plasminogen Fibrinolysis male genital tract The blood of man is rich in plasminogen, the inactive precursor of plasmin, a protease (Astrup, 1956a); the most characteristic action of plasmin is the digestion of fibrin, i.e. fibrinolysis. Many tissues, including the prostate (Rasmussen and Albrechtsen, 1960a), contain substances which can activate plasminogen, and thus initiate fibrinolysis, and it has been assumed that both the excessive fibrinolysis seen in the blood of some patients with prostatic disease (Tagnon, Whitmore, Schulman and Kravitz, 1953a), and in prostatic surgery (Lombardo, 1957), is due to the release of this activator into the blood stream (Fearnley, 1965). Human semen contains a substance which can activate the blood fibrinolytic system (von Kaulla and Shettles, 1953). Indeed, when human seminal fluid is ejaculated, it undergoes a process resembling the clotting and fibrinolysis of the blood, by coagulating then liquefying spontaneously. The coagulum is formed when a fibrinogenlike protein secreted by the seminal vesicles is acted upon by a clotting enzyme from the prostate (Mann, 1964). Coagulation is followed within about 20 minutes by liquefactionliquefaction of the clots by an enzyme assumed to come from the prostate (Huggins and Neal, 1942). This enzyme resembles plasmin in that it is a protease acting on a fibrin-like substrate, and that it is derived from an inactive precursor. 2020-05-29T13:23:45Z 2020-05-29T13:23:45Z 1970 2020-04-08T07:28:49Z Master Thesis Masters https://hdl.handle.net/11427/32014 eng application/pdf Department of Surgery Faculty of Health Sciences |
| spellingShingle | Plasminogen Fibrinolysis male genital tract Kester, Ralph Charles The distribution of plasminogen activator in the male genital tract |
| thesis_degree_str | Master's |
| title | The distribution of plasminogen activator in the male genital tract |
| title_full | The distribution of plasminogen activator in the male genital tract |
| title_fullStr | The distribution of plasminogen activator in the male genital tract |
| title_full_unstemmed | The distribution of plasminogen activator in the male genital tract |
| title_short | The distribution of plasminogen activator in the male genital tract |
| title_sort | distribution of plasminogen activator in the male genital tract |
| topic | Plasminogen Fibrinolysis male genital tract |
| url | https://hdl.handle.net/11427/32014 |
| work_keys_str_mv | AT kesterralphcharles thedistributionofplasminogenactivatorinthemalegenitaltract AT kesterralphcharles distributionofplasminogenactivatorinthemalegenitaltract |