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Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development
Bibliography: leaves 139-178.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Human Biology
2014
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| _version_ | 1867613306291748864 |
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| access_status_str | Open Access |
| author | Smit, Marithea |
| author2 | Neuman, Toomas |
| author_browse | Neuman, Toomas Smit, Marithea |
| author_facet | Neuman, Toomas Smit, Marithea |
| author_sort | Smit, Marithea |
| collection | Thesis |
| description | Bibliography: leaves 139-178. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3203 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:00.978Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3203 Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development Smit, Marithea Neuman, Toomas Human Biology Bibliography: leaves 139-178. Induction of tumor differentiation through manipulation of regulatory genes is a relatively unexplored area of cancer therapy, however, it might suggest and additional approach for tumour-specific treatment. Therefore, in view of this idea, the present study hypothesized that neuroblastomas (NBs) and pulmonary neuroendocrine tumors (NETs), which are neoplasms of neural origin, are molecularly different based on their expression of regulatory genes and that exposure to extrinsic factors will alter their growth potential. Using reverse-transcription polymerase chain reaction (RT-PCR) analysis, the present study compared the expression of about 50 regulatory genes that are expressed at early stages of neurogenesis in five human NBs and NETs, also upon GDNF/TGF-β1 and retinoic acid (RA) treatment. According to our results, individual NBs and NETs reflected a certain stage of neural development characterized by their expression of discrete sets of regulatory genes. 2014-07-28T18:15:27Z 2014-07-28T18:15:27Z 2002 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3203 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Human Biology Smit, Marithea Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development |
| thesis_degree_str | Doctoral |
| title | Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development |
| title_full | Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development |
| title_fullStr | Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development |
| title_full_unstemmed | Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development |
| title_short | Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development |
| title_sort | specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling based interpretation of cellular development |
| topic | Human Biology |
| url | http://hdl.handle.net/11427/3203 |
| work_keys_str_mv | AT smitmarithea specificdiagnosisforeffectivetreatmentofneuroblastomasandpulmonaryneuroendocrinetumorsthroughtranscriptionalprofilingbasedinterpretationofcellulardevelopment |