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An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests
The purpose of this project has been to test the postulate that high blood levels of pyruvate encountered in certain conditions such as steroid excess, diabetes mellitus under certain circumstances, and thiamine deficiency, are due to defective removal of pyruvate rather than excessive production. S...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2020
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| _version_ | 1867614196759265280 |
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| access_status_str | Open Access |
| author | Lange, Leo Stanley |
| author_browse | Lange, Leo Stanley |
| author_facet | Lange, Leo Stanley |
| author_sort | Lange, Leo Stanley |
| collection | Thesis |
| description | The purpose of this project has been to test the postulate that high blood levels of pyruvate encountered in certain conditions such as steroid excess, diabetes mellitus under certain circumstances, and thiamine deficiency, are due to defective removal of pyruvate rather than excessive production. Specific methods of assay and direct studies of pyruvate tolerance were used. Intermediary carbohydrate metabolism was studied in a total of 109 subjects. The history of thiamine deficiency and of the concept of ensymes is outlined and the literature on pyruvate estimation and study in various clinical conditions is reviewed. Direct tests of pyruvate tolerance are discussed and the biochemistry if glucose breakdown is described. the history of analytical methodology for pyruvate is recounted. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/32043 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:48:12.405Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/32043 An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests Lange, Leo Stanley metabolism pyruvates The purpose of this project has been to test the postulate that high blood levels of pyruvate encountered in certain conditions such as steroid excess, diabetes mellitus under certain circumstances, and thiamine deficiency, are due to defective removal of pyruvate rather than excessive production. Specific methods of assay and direct studies of pyruvate tolerance were used. Intermediary carbohydrate metabolism was studied in a total of 109 subjects. The history of thiamine deficiency and of the concept of ensymes is outlined and the literature on pyruvate estimation and study in various clinical conditions is reviewed. Direct tests of pyruvate tolerance are discussed and the biochemistry if glucose breakdown is described. the history of analytical methodology for pyruvate is recounted. 2020-06-08T09:17:51Z 2020-06-08T09:17:51Z 1967 2020-04-08T08:24:14Z Master Thesis Masters https://hdl.handle.net/11427/32043 eng application/pdf Department of Medicine Faculty of Health Sciences |
| spellingShingle | metabolism pyruvates Lange, Leo Stanley An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests |
| thesis_degree_str | Master's |
| title | An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests |
| title_full | An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests |
| title_fullStr | An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests |
| title_full_unstemmed | An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests |
| title_short | An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests |
| title_sort | investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests |
| topic | metabolism pyruvates |
| url | https://hdl.handle.net/11427/32043 |
| work_keys_str_mv | AT langeleostanley aninvestigationofcertainaspectsofpyruvatemetabolisminmanbyindirectanddirecttolerancetests AT langeleostanley investigationofcertainaspectsofpyruvatemetabolisminmanbyindirectanddirecttolerancetests |