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Aspects of structure-activity relationships and physiology of gastrin and related peptides
When, in 1973, I embarked upon this study, the hormone gastrin seemed a suitable hormone to study with regard to investigation of structure-activity relationships and physiology of a peptide hormone. Gastrin was best known at that stage as a linear peptide comprising 17 amino acids, which was stable...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Medicine
2020
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| _version_ | 1867613261256458240 |
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| access_status_str | Open Access |
| author | Napier, Beverley Jean |
| author2 | Vinik, Aaron I |
| author_browse | Napier, Beverley Jean Vinik, Aaron I |
| author_facet | Vinik, Aaron I Napier, Beverley Jean |
| author_sort | Napier, Beverley Jean |
| collection | Thesis |
| description | When, in 1973, I embarked upon this study, the hormone gastrin seemed a suitable hormone to study with regard to investigation of structure-activity relationships and physiology of a peptide hormone. Gastrin was best known at that stage as a linear peptide comprising 17 amino acids, which was stable at room temperature and was resistant to degradation by vigorous treatments such as boiling {Gregory and Tracy, 1964; Berson and Yalow, 1971; Yalow and Berson, 1972) and pH extremes (Piszkiewicz, 1974). Such a molecule could thus be studied at room temperature, using conventional biochemical techniques, without the need for any special precautions to preserve its integrity. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/32048 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:19.547Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/32048 Aspects of structure-activity relationships and physiology of gastrin and related peptides Napier, Beverley Jean Vinik, Aaron I Peptides Physiology Gastrins When, in 1973, I embarked upon this study, the hormone gastrin seemed a suitable hormone to study with regard to investigation of structure-activity relationships and physiology of a peptide hormone. Gastrin was best known at that stage as a linear peptide comprising 17 amino acids, which was stable at room temperature and was resistant to degradation by vigorous treatments such as boiling {Gregory and Tracy, 1964; Berson and Yalow, 1971; Yalow and Berson, 1972) and pH extremes (Piszkiewicz, 1974). Such a molecule could thus be studied at room temperature, using conventional biochemical techniques, without the need for any special precautions to preserve its integrity. 2020-06-10T07:47:51Z 2020-06-10T07:47:51Z 1978 2020-04-09T09:48:40Z Doctoral Thesis Doctoral http://hdl.handle.net/11427/32048 eng application/pdf Department of Medicine Faculty of Health Sciences |
| spellingShingle | Peptides Physiology Gastrins Napier, Beverley Jean Aspects of structure-activity relationships and physiology of gastrin and related peptides |
| thesis_degree_str | Doctoral |
| title | Aspects of structure-activity relationships and physiology of gastrin and related peptides |
| title_full | Aspects of structure-activity relationships and physiology of gastrin and related peptides |
| title_fullStr | Aspects of structure-activity relationships and physiology of gastrin and related peptides |
| title_full_unstemmed | Aspects of structure-activity relationships and physiology of gastrin and related peptides |
| title_short | Aspects of structure-activity relationships and physiology of gastrin and related peptides |
| title_sort | aspects of structure activity relationships and physiology of gastrin and related peptides |
| topic | Peptides Physiology Gastrins |
| url | http://hdl.handle.net/11427/32048 |
| work_keys_str_mv | AT napierbeverleyjean aspectsofstructureactivityrelationshipsandphysiologyofgastrinandrelatedpeptides |