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Studies on the degradation of haemoglobin
The chemical relationship which exists between haemoglobin and bile pigments was first established in 1933, when, after monumental studies covering a period of 24 years, Hans Fischer and his colleagues succeeded in synthesizing bile pigments and protoporphyrin. He thereby demonstrated the fundamenta...
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| Format: | Thesis |
| Language: | English |
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Division of Medical Biochemistry
2020
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| _version_ | 1867613158273712128 |
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| access_status_str | Open Access |
| author | Green, Margaret |
| author2 | Kench, J E |
| author_browse | Green, Margaret Kench, J E |
| author_facet | Kench, J E Green, Margaret |
| author_sort | Green, Margaret |
| collection | Thesis |
| description | The chemical relationship which exists between haemoglobin and bile pigments was first established in 1933, when, after monumental studies covering a period of 24 years, Hans Fischer and his colleagues succeeded in synthesizing bile pigments and protoporphyrin. He thereby demonstrated the fundamental tetrapyrrolic structure which is common to both haem and bilirubin. Prior to this, in vivo experiments on dogs performed by Mann, Sheard, Bollman and Blades showed that haemoglobin, injected into the arterial blood of the spleen or bone-marrow, produced a rise in the bilirubin content of the venous blood. Haematin was also evident in both arterial and venous blood. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/32056 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:41.113Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/32056 Studies on the degradation of haemoglobin Green, Margaret Kench, J E Medical Biochemistry Hemoglobins The chemical relationship which exists between haemoglobin and bile pigments was first established in 1933, when, after monumental studies covering a period of 24 years, Hans Fischer and his colleagues succeeded in synthesizing bile pigments and protoporphyrin. He thereby demonstrated the fundamental tetrapyrrolic structure which is common to both haem and bilirubin. Prior to this, in vivo experiments on dogs performed by Mann, Sheard, Bollman and Blades showed that haemoglobin, injected into the arterial blood of the spleen or bone-marrow, produced a rise in the bilirubin content of the venous blood. Haematin was also evident in both arterial and venous blood. 2020-06-10T08:26:37Z 2020-06-10T08:26:37Z 1966 2020-04-06T19:01:27Z Master Thesis Masters http://hdl.handle.net/11427/32056 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences |
| spellingShingle | Medical Biochemistry Hemoglobins Green, Margaret Studies on the degradation of haemoglobin |
| thesis_degree_str | Master's |
| title | Studies on the degradation of haemoglobin |
| title_full | Studies on the degradation of haemoglobin |
| title_fullStr | Studies on the degradation of haemoglobin |
| title_full_unstemmed | Studies on the degradation of haemoglobin |
| title_short | Studies on the degradation of haemoglobin |
| title_sort | studies on the degradation of haemoglobin |
| topic | Medical Biochemistry Hemoglobins |
| url | http://hdl.handle.net/11427/32056 |
| work_keys_str_mv | AT greenmargaret studiesonthedegradationofhaemoglobin |