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Histone modification during the induction of tyrosine transaminase
"The induction phenomenon is a useful model for the study of mechanisms which regulate the synthesis of specific enzymes in mammalian tissue, as well as for the role of hormones in this process". The in vivo administration of hormone initiates a chain of reactions which culminate in the increase of...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2020
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| _version_ | 1867611296733593600 |
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| access_status_str | Open Access |
| author | Graaff, G De V |
| author2 | von Holt, C |
| author_browse | Graaff, G De V von Holt, C |
| author_facet | von Holt, C Graaff, G De V |
| author_sort | Graaff, G De V |
| collection | Thesis |
| description | "The induction phenomenon is a useful model for the study of mechanisms which regulate the synthesis of specific enzymes in mammalian tissue, as well as for the role of hormones in this process". The in vivo administration of hormone initiates a chain of reactions which culminate in the increase of protein synthesis. Many hepatic enzymes are thus affected resulting in an increase of their activity. Studies of the giant chromosomes in the salivary glands
of Chironomus tentans provided the first indications that the earliest intracellular effects of hormone administration are at the genetic level. Injection of the insect moulting hormone, ecdysone, into last instar larvae of Chironomus tentans results in puff formation at specific loci of the chromosomes shortly after hormone administration. Since puffs are local and reversible alterations of the chromosome, formed at sites which are active in the synthesis of informational RNA, their formation shows a change in activity of particular gene loci in response to ecdysone. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/32057 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/32057 Histone modification during the induction of tyrosine transaminase Graaff, G De V von Holt, C Tyrosine Transaminase "The induction phenomenon is a useful model for the study of mechanisms which regulate the synthesis of specific enzymes in mammalian tissue, as well as for the role of hormones in this process". The in vivo administration of hormone initiates a chain of reactions which culminate in the increase of protein synthesis. Many hepatic enzymes are thus affected resulting in an increase of their activity. Studies of the giant chromosomes in the salivary glands of Chironomus tentans provided the first indications that the earliest intracellular effects of hormone administration are at the genetic level. Injection of the insect moulting hormone, ecdysone, into last instar larvae of Chironomus tentans results in puff formation at specific loci of the chromosomes shortly after hormone administration. Since puffs are local and reversible alterations of the chromosome, formed at sites which are active in the synthesis of informational RNA, their formation shows a change in activity of particular gene loci in response to ecdysone. 2020-06-10T08:28:54Z 2020-06-10T08:28:54Z 1972 2020-04-07T07:16:34Z Master Thesis Masters http://hdl.handle.net/11427/32057 eng application/pdf Department of Chemistry Faculty of Science |
| spellingShingle | Tyrosine Transaminase Graaff, G De V Histone modification during the induction of tyrosine transaminase |
| thesis_degree_str | Master's |
| title | Histone modification during the induction of tyrosine transaminase |
| title_full | Histone modification during the induction of tyrosine transaminase |
| title_fullStr | Histone modification during the induction of tyrosine transaminase |
| title_full_unstemmed | Histone modification during the induction of tyrosine transaminase |
| title_short | Histone modification during the induction of tyrosine transaminase |
| title_sort | histone modification during the induction of tyrosine transaminase |
| topic | Tyrosine Transaminase |
| url | http://hdl.handle.net/11427/32057 |
| work_keys_str_mv | AT graaffgdev histonemodificationduringtheinductionoftyrosinetransaminase |