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A two-year review of necrotising enterocolitis in very low birth weight infants (<1500g) in a South African tertiary hospital
Background: There is paucity of local data on the profile of preterm very low birth weight (VLBW) infants who develop moderate to severe necrotising enterocolitis (NEC) and their outcomes. Methods: A retrospective folder review of VLBWs who developed Modified Bell’s stage II NEC or higher at Groote...
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| Format: | Thesis |
| Language: | English |
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Department of Paediatrics and Child Health
2020
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| _version_ | 1867613237525086208 |
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| access_status_str | Open Access |
| author | Gumede, Mbalenhle Purity |
| author2 | Tooke, Lloyd |
| author_browse | Gumede, Mbalenhle Purity Tooke, Lloyd |
| author_facet | Tooke, Lloyd Gumede, Mbalenhle Purity |
| author_sort | Gumede, Mbalenhle Purity |
| collection | Thesis |
| description | Background: There is paucity of local data on the profile of preterm very low birth weight (VLBW) infants who develop moderate to severe necrotising enterocolitis (NEC) and their outcomes. Methods: A retrospective folder review of VLBWs who developed Modified Bell’s stage II NEC or higher at Groote Schuur Hospital (GSH) nursery between January 2012 and December 2013 was performed. Outcomes were defined as requirement for surgery and mortality. Results: Forty seven infants were included (5% incidence). Gestational ages ranged from 25 to 36 weeks, 53% were 10 mg/L (60%) and subserosal gas radiologically (84%). Half the patients received mechanical ventilation, 38% required inotropes. The mortality rate was 64%. Three of the five infants that received surgery survived. Conclusion: Despite a similar incidence to global counterparts, our VLBW infants have severe NEC disease often requiring advanced life support, with a high mortality rate. HIV exposure may increase the risk of NEC development. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/32072 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:57.328Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Paediatrics and Child Health |
| publisherStr | Department of Paediatrics and Child Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/32072 A two-year review of necrotising enterocolitis in very low birth weight infants (<1500g) in a South African tertiary hospital Gumede, Mbalenhle Purity Tooke, Lloyd Medicine Background: There is paucity of local data on the profile of preterm very low birth weight (VLBW) infants who develop moderate to severe necrotising enterocolitis (NEC) and their outcomes. Methods: A retrospective folder review of VLBWs who developed Modified Bell’s stage II NEC or higher at Groote Schuur Hospital (GSH) nursery between January 2012 and December 2013 was performed. Outcomes were defined as requirement for surgery and mortality. Results: Forty seven infants were included (5% incidence). Gestational ages ranged from 25 to 36 weeks, 53% were 10 mg/L (60%) and subserosal gas radiologically (84%). Half the patients received mechanical ventilation, 38% required inotropes. The mortality rate was 64%. Three of the five infants that received surgery survived. Conclusion: Despite a similar incidence to global counterparts, our VLBW infants have severe NEC disease often requiring advanced life support, with a high mortality rate. HIV exposure may increase the risk of NEC development. 2020-06-17T19:55:59Z 2020-06-17T19:55:59Z 2019 2020-06-17T13:19:35Z Master Thesis Masters https://hdl.handle.net/11427/32072 eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences |
| spellingShingle | Medicine Gumede, Mbalenhle Purity A two-year review of necrotising enterocolitis in very low birth weight infants (<1500g) in a South African tertiary hospital |
| thesis_degree_str | Master's |
| title | A two-year review of necrotising enterocolitis in very low birth weight infants (<1500g) in a South African tertiary hospital |
| title_full | A two-year review of necrotising enterocolitis in very low birth weight infants (<1500g) in a South African tertiary hospital |
| title_fullStr | A two-year review of necrotising enterocolitis in very low birth weight infants (<1500g) in a South African tertiary hospital |
| title_full_unstemmed | A two-year review of necrotising enterocolitis in very low birth weight infants (<1500g) in a South African tertiary hospital |
| title_short | A two-year review of necrotising enterocolitis in very low birth weight infants (<1500g) in a South African tertiary hospital |
| title_sort | two year review of necrotising enterocolitis in very low birth weight infants 1500g in a south african tertiary hospital |
| topic | Medicine |
| url | https://hdl.handle.net/11427/32072 |
| work_keys_str_mv | AT gumedembalenhlepurity atwoyearreviewofnecrotisingenterocolitisinverylowbirthweightinfants1500ginasouthafricantertiaryhospital AT gumedembalenhlepurity twoyearreviewofnecrotisingenterocolitisinverylowbirthweightinfants1500ginasouthafricantertiaryhospital |