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Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Human Biology
2014
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| _version_ | 1867613870446608384 |
|---|---|
| access_status_str | Open Access |
| author | Boonzaier, Natalie Rosella |
| author2 | Meintjes, Ernesta |
| author_browse | Boonzaier, Natalie Rosella Meintjes, Ernesta |
| author_facet | Meintjes, Ernesta Boonzaier, Natalie Rosella |
| author_sort | Boonzaier, Natalie Rosella |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3225 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:43:01.209Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3225 Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study Boonzaier, Natalie Rosella Meintjes, Ernesta Warton, Christopher MED Includes abstract. Includes bibliographical references. Years of research have demonstrated that prenatal exposure to alcohol contributes to a range of effects in exposed children. These include problems in attention and hyperactivity, deficits in memory and learning, and problems with social, as well as emotional development. Past research has demonstrated that the cerebellum is a significant target of the teratogenic effects of alcohol. The aim of this study was to determine whether prenatal exposure to alcohol has specific effects on the volumes of specific lobules of the cerebellum. Lobule tracing was performed manually, with Multitracer, using a refined methodology. Lobule volumes (normalized for total cerebellar cortical volume) were analysed as functions of diagnosis as well as alcohol exposure. Lobules IX and X were affected when analysing normalized volumes as a function of diagnosis, with the fetal alcohol syndrome diagnostic group being most specifically affected. Significant differences between sex groups were found only for right lobules I-V and left lobule VIII, and hemisphere differences were found in lobule X. When analysing normalized lobule volume as a function of alcohol exposure, in the left hemisphere, lobules I-V showed positive correlations with alcohol exposure, suggesting that this region is relatively spared. Lobule IX and the vermis of the right hemisphere showed negative correlations with alcohol exposure. The strongest negative correlations were found for measures of absolute alcohol per day averaged across the period of pregnancy as opposed to at time of conception. Overall findings suggest that prenatal alcohol exposure causes disproportionate reductions in volume in specific lobules of the cerebellums of children with fetal alcohol spectrum disorders. 2014-07-28T18:16:05Z 2014-07-28T18:16:05Z 2012 Master Thesis Masters MSc http://hdl.handle.net/11427/3225 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | MED Boonzaier, Natalie Rosella Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study |
| thesis_degree_str | Master's |
| title | Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study |
| title_full | Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study |
| title_fullStr | Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study |
| title_full_unstemmed | Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study |
| title_short | Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study |
| title_sort | effects of prenatal alcohol exposure on cerebellar volume in children an mri study |
| topic | MED |
| url | http://hdl.handle.net/11427/3225 |
| work_keys_str_mv | AT boonzaiernatalierosella effectsofprenatalalcoholexposureoncerebellarvolumeinchildrenanmristudy |