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Longitudinal analysis of Brain Metabolite levels for HIV infected Children from ages five to eleven
HIV infected (HIV+) children initiate antiretroviral therapy (ART) early in life and remain on it lifelong. However, the long-term impact of ART and HIV on the maturing brain is not well documented and longitudinal neuroimaging studies are rare, especially in developing countries most heavily impact...
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| Format: | Thesis |
| Language: | English |
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Department of Statistical Sciences
2020
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| _version_ | 1867613217624162304 |
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| access_status_str | Open Access |
| author | Van Biljon, Noëlle |
| author2 | Little, Francesca |
| author_browse | Little, Francesca Van Biljon, Noëlle |
| author_facet | Little, Francesca Van Biljon, Noëlle |
| author_sort | Van Biljon, Noëlle |
| collection | Thesis |
| description | HIV infected (HIV+) children initiate antiretroviral therapy (ART) early in life and remain on it lifelong. However, the long-term impact of ART and HIV on the maturing brain is not well documented and longitudinal neuroimaging studies are rare, especially in developing countries most heavily impacted by HIV/AIDS where access to imaging resources are limited. We have examined HIV related changes in metabolite level trajectories from 5-11 years in three brain regions using Magnetic Resonance Spectroscopy (MRS). We used univariate linear mixed effect models to identify independent profiles of the metabolites measured in each region of the brain. To explore the metabolite trends in a multivariate setting we generated multilevel mixed effects models, and correlated response models. There was an element of confounding introduced through the change of MRI scanner during the follow-up period and we compare different methods to resolve this issue. Consequently, we did observe differences in metabolite profiles from HIV+ children compared to HIV uninfected (HIV-) controls. This suggests that while these children are on ART treatment, there is still some underlying effect on their neurochemistry which sets their development apart from the normal healthy profiles we expect. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/32370 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:38.580Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Statistical Sciences |
| publisherStr | Department of Statistical Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/32370 Longitudinal analysis of Brain Metabolite levels for HIV infected Children from ages five to eleven Van Biljon, Noëlle Little, Francesca Meintjes, Ernesta Holmes, Martha Robertson, Frances Biostatistics HIV infected (HIV+) children initiate antiretroviral therapy (ART) early in life and remain on it lifelong. However, the long-term impact of ART and HIV on the maturing brain is not well documented and longitudinal neuroimaging studies are rare, especially in developing countries most heavily impacted by HIV/AIDS where access to imaging resources are limited. We have examined HIV related changes in metabolite level trajectories from 5-11 years in three brain regions using Magnetic Resonance Spectroscopy (MRS). We used univariate linear mixed effect models to identify independent profiles of the metabolites measured in each region of the brain. To explore the metabolite trends in a multivariate setting we generated multilevel mixed effects models, and correlated response models. There was an element of confounding introduced through the change of MRI scanner during the follow-up period and we compare different methods to resolve this issue. Consequently, we did observe differences in metabolite profiles from HIV+ children compared to HIV uninfected (HIV-) controls. This suggests that while these children are on ART treatment, there is still some underlying effect on their neurochemistry which sets their development apart from the normal healthy profiles we expect. 2020-11-10T14:49:56Z 2020-11-10T14:49:56Z 2020 2020-11-10T09:53:20Z Master Thesis Masters MSc http://hdl.handle.net/11427/32370 eng application/pdf Department of Statistical Sciences Faculty of Science |
| spellingShingle | Biostatistics Van Biljon, Noëlle Longitudinal analysis of Brain Metabolite levels for HIV infected Children from ages five to eleven |
| thesis_degree_str | Master's |
| title | Longitudinal analysis of Brain Metabolite levels for HIV infected Children from ages five to eleven |
| title_full | Longitudinal analysis of Brain Metabolite levels for HIV infected Children from ages five to eleven |
| title_fullStr | Longitudinal analysis of Brain Metabolite levels for HIV infected Children from ages five to eleven |
| title_full_unstemmed | Longitudinal analysis of Brain Metabolite levels for HIV infected Children from ages five to eleven |
| title_short | Longitudinal analysis of Brain Metabolite levels for HIV infected Children from ages five to eleven |
| title_sort | longitudinal analysis of brain metabolite levels for hiv infected children from ages five to eleven |
| topic | Biostatistics |
| url | http://hdl.handle.net/11427/32370 |
| work_keys_str_mv | AT vanbiljonnoelle longitudinalanalysisofbrainmetabolitelevelsforhivinfectedchildrenfromagesfivetoeleven |