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Modelling Multivariate Nonlinear Vaccine Induced Immune Responses
Interpretable statistical models for multivariate vaccine induced immune response data are important as they provide a rigorous means of deciding which vaccine candidates should be advanced in the clinical trials process. We consider applications of several different statistical models to a vaccine...
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| Format: | Thesis |
| Language: | English |
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Department of Statistical Sciences
2020
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| _version_ | 1867611280183918592 |
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| access_status_str | Open Access |
| author | Lapham, Brendon M |
| author2 | Little, Francesca |
| author_browse | Lapham, Brendon M Little, Francesca |
| author_facet | Little, Francesca Lapham, Brendon M |
| author_sort | Lapham, Brendon M |
| collection | Thesis |
| description | Interpretable statistical models for multivariate vaccine induced immune response data are important as they provide a rigorous means of deciding which vaccine candidates should be advanced in the clinical trials process. We consider applications of several different statistical models to a vaccine data set which contains multivariate immune responses for several novel Tuberculosis vaccines and the current BCG vaccine. The immune responses in the data set have several features which the models need to account for. In particular, the models need to account for the multivariate repeated measures for the subjects, the nonlinear profiles of the immune responses, and the zero-inflated skew distributions of the immune responses. We find that Tweedie multivariate generalised linear mixed effect and latent variable models with cubic B-splines perform well for this data set relative to linear, nonlinear, and univariate Tweedie generalised linear mixed effect models. In addition, the Tweedie multivariate generalised linear mixed effect and latent variable models have several advantages over the other models we consider and are also capable of interpretation; importantly, we are able to draw clinical conclusions about which novel TB vaccine candidates appear to be the most promising. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/32385 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Statistical Sciences |
| publisherStr | Department of Statistical Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/32385 Modelling Multivariate Nonlinear Vaccine Induced Immune Responses Lapham, Brendon M Little, Francesca Statistics Interpretable statistical models for multivariate vaccine induced immune response data are important as they provide a rigorous means of deciding which vaccine candidates should be advanced in the clinical trials process. We consider applications of several different statistical models to a vaccine data set which contains multivariate immune responses for several novel Tuberculosis vaccines and the current BCG vaccine. The immune responses in the data set have several features which the models need to account for. In particular, the models need to account for the multivariate repeated measures for the subjects, the nonlinear profiles of the immune responses, and the zero-inflated skew distributions of the immune responses. We find that Tweedie multivariate generalised linear mixed effect and latent variable models with cubic B-splines perform well for this data set relative to linear, nonlinear, and univariate Tweedie generalised linear mixed effect models. In addition, the Tweedie multivariate generalised linear mixed effect and latent variable models have several advantages over the other models we consider and are also capable of interpretation; importantly, we are able to draw clinical conclusions about which novel TB vaccine candidates appear to be the most promising. 2020-11-11T11:58:28Z 2020-11-11T11:58:28Z 2020 2020-11-11T07:28:43Z Master Thesis Masters MSc http://hdl.handle.net/11427/32385 eng application/pdf Department of Statistical Sciences Faculty of Science |
| spellingShingle | Statistics Lapham, Brendon M Modelling Multivariate Nonlinear Vaccine Induced Immune Responses |
| thesis_degree_str | Master's |
| title | Modelling Multivariate Nonlinear Vaccine Induced Immune Responses |
| title_full | Modelling Multivariate Nonlinear Vaccine Induced Immune Responses |
| title_fullStr | Modelling Multivariate Nonlinear Vaccine Induced Immune Responses |
| title_full_unstemmed | Modelling Multivariate Nonlinear Vaccine Induced Immune Responses |
| title_short | Modelling Multivariate Nonlinear Vaccine Induced Immune Responses |
| title_sort | modelling multivariate nonlinear vaccine induced immune responses |
| topic | Statistics |
| url | http://hdl.handle.net/11427/32385 |
| work_keys_str_mv | AT laphambrendonm modellingmultivariatenonlinearvaccineinducedimmuneresponses |