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Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Biomedical Engineering
2014
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| _version_ | 1867613270167257088 |
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| access_status_str | Open Access |
| author | Herron, Robyn |
| author2 | Meintjes, Ernesta M |
| author_browse | Herron, Robyn Meintjes, Ernesta M |
| author_facet | Meintjes, Ernesta M Herron, Robyn |
| author_sort | Herron, Robyn |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3244 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:28.738Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Biomedical Engineering |
| publisherStr | Division of Biomedical Engineering |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3244 Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing Herron, Robyn Meintjes, Ernesta M Biomedical Engineering Includes abstract. Includes bibliographical references (leaves 84-91). Maternal drinking during pregnancy is a significant problem in the Western Cape, South Africa, with an accompanying high incidence of children diagnosed with foetal alcohol spectrum disorder (FASD). Little is known about the neural correlates governing the disorder that manifest as behavioural abnormalities and cognitive impairments, particularly in arithmethic calculation, repeatedly reported in affected children. The effect of prenatal alcohol exposure on number processing in children was investigated in a functional magnetic resonance imaging (fMRI) study (Meintjes et al., 2007). The results indicate significant differences in activation between alcohol-exposed and non-exposed control children during Exact Addition and Proximity Judgement tasks. This raised the question of whether the groups of children differ in functional connectivity during the number processing tasks. Therefore, the objective of this study was to analyse connectivity between functionally specialised brain areas in the previously collected fMRI data. The fMRI data of 14 controls and 7 alcohol-exposed children for Exact Addition and 15 controls and 9 alcohol-exposed children for Proximity Judgement was available for analysis. A primary aim was to determine normal functional connectivity in control children during number processing and a secondary aim, to investigate any differences in functional connectivity in children with FASD. 2014-07-28T18:16:43Z 2014-07-28T18:16:43Z 2008 Master Thesis Masters MSc http://hdl.handle.net/11427/3244 eng application/pdf Division of Biomedical Engineering Faculty of Health Sciences University of Cape Town |
| spellingShingle | Biomedical Engineering Herron, Robyn Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing |
| thesis_degree_str | Master's |
| title | Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing |
| title_full | Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing |
| title_fullStr | Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing |
| title_full_unstemmed | Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing |
| title_short | Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing |
| title_sort | connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing |
| topic | Biomedical Engineering |
| url | http://hdl.handle.net/11427/3244 |
| work_keys_str_mv | AT herronrobyn connectivityanalysisofbrainfunctioninchildrenwithfoetalalcoholspectrumdisorderandcontrolchildrenduringnumberprocessing |