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Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Human Biology
2014
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| _version_ | 1867614196997292032 |
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| access_status_str | Open Access |
| author | Joffe, Yael |
| author2 | Goedecke, Julia |
| author_browse | Goedecke, Julia Joffe, Yael |
| author_facet | Goedecke, Julia Joffe, Yael |
| author_sort | Joffe, Yael |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3253 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:48:12.632Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3253 Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women Joffe, Yael Goedecke, Julia Collins, Malcolm Van der Merwe, Lize Human Biology Includes abstract. Includes bibliographical references. The primary aim of the thesis was to investigate associations between TNFA (TNFA-308 G>A and -238 G>A) and IL-6 (-174 G>C, IVS3+281 G>T, IVS4+869 A>G) sequence variants and obesity and serum lipid concentrations in black and white SA women. This included identifying sequence variants in the IL-6 gene with a reported high heterozygosity in both the white and black SA populations (rs1554606 and sr2069845). Dietary intake data of adequate reporters was then included in the analysis to investigate whether dietary fatty acid intake modulated the interactions between the TNFA and IL-6 SNPs (TNFA -308 G>A and -238 G>A & IL-6 -174 G>C, IVS3+281 G>T, IVS4+869 A>G) and obesity, measures of adiposity and serum lipid concentrations, and whether interactions identified differed between black and white women. 2014-07-28T18:16:55Z 2014-07-28T18:16:55Z 2013 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3253 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Human Biology Joffe, Yael Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women |
| thesis_degree_str | Doctoral |
| title | Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women |
| title_full | Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women |
| title_fullStr | Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women |
| title_full_unstemmed | Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women |
| title_short | Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women |
| title_sort | dietary fat modulates the relationship between polymorphisms in the tnfa and il 6 genes and obesity and serum lipid concentrations in black and white south afican women |
| topic | Human Biology |
| url | http://hdl.handle.net/11427/3253 |
| work_keys_str_mv | AT joffeyael dietaryfatmodulatestherelationshipbetweenpolymorphismsinthetnfaandil6genesandobesityandserumlipidconcentrationsinblackandwhitesouthaficanwomen |