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Volumetric modulated Arc Therapy versus 3D conformal radiotherapy in the treatment of locally advanced cervical cancer. A single institution, comparative dosimetric study

Background: External Beam Radiotherapy is essential in the management of locally advanced cervical cancer (LACC). Generally, VMAT is thought to achieve higher conformity to the Planned Target Volume (PTV) and better sparing of organs at risk (OAR) when compared to 3D-CRT. This study focused on these...

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Main Author: Bhagaloo, Visham
Other Authors: Fakie, Nazia
Format: Thesis
Language:English
Published: Division of Radiology 2021
Subjects:
Cervical cancer
VMAT
3D-CRT
radiation therapy
dosimetry
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access_status_str Open Access
author Bhagaloo, Visham
author2 Fakie, Nazia
author_browse Bhagaloo, Visham
Fakie, Nazia
author_facet Fakie, Nazia
Bhagaloo, Visham
author_sort Bhagaloo, Visham
collection Thesis
description Background: External Beam Radiotherapy is essential in the management of locally advanced cervical cancer (LACC). Generally, VMAT is thought to achieve higher conformity to the Planned Target Volume (PTV) and better sparing of organs at risk (OAR) when compared to 3D-CRT. This study focused on these principles as it applied to treatment and potential toxicity in the management of LACC. Aim: To compare dosimetric parameters between VMAT and 3D-CRT in the management of LACC. Setting: The study analysed patients treated at Groote Schuur Hospital between May and December 2017. Method: A non-randomized comparative retrospective study. EBRT plans for 3D-CRT and VMAT were generated and data on treatment parameters for PTV D50%, Dmax, Dmean, Conformity Index (CI), Homogeneity Index, Treated Volume (TV), Irradiated Volume (IV) and OAR constraints; femoral heads, bladder, bowel bag, rectum and bone marrow were collected. Results: Of the 45 patients assessed, VMAT showed significantly lower treatment parameter values for CI (1.09 vs 1.49; p< .001) whereas, 3D-CRT showed lower Dmax (48.1Gy vs 49.2Gy; p< .001) and rectum (88.5% vs 96%). A reduced 3D-CRT dose was noted for bladder Dmax (47.4Gy vs 48.3Gy; p< .001). Conclusion: VMAT offered a superior dosimetric option, with better OAR dose sparing and optimal tumour dosimetry.
format Thesis
id oai:open.uct.ac.za:11427/32601
institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:34:32.198Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2021
publishDateRange 2021
publishDateSort 2021
publisher Division of Radiology
publisherStr Division of Radiology
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/32601 Volumetric modulated Arc Therapy versus 3D conformal radiotherapy in the treatment of locally advanced cervical cancer. A single institution, comparative dosimetric study Bhagaloo, Visham Fakie, Nazia Cervical cancer VMAT 3D-CRT radiation therapy dosimetry Background: External Beam Radiotherapy is essential in the management of locally advanced cervical cancer (LACC). Generally, VMAT is thought to achieve higher conformity to the Planned Target Volume (PTV) and better sparing of organs at risk (OAR) when compared to 3D-CRT. This study focused on these principles as it applied to treatment and potential toxicity in the management of LACC. Aim: To compare dosimetric parameters between VMAT and 3D-CRT in the management of LACC. Setting: The study analysed patients treated at Groote Schuur Hospital between May and December 2017. Method: A non-randomized comparative retrospective study. EBRT plans for 3D-CRT and VMAT were generated and data on treatment parameters for PTV D50%, Dmax, Dmean, Conformity Index (CI), Homogeneity Index, Treated Volume (TV), Irradiated Volume (IV) and OAR constraints; femoral heads, bladder, bowel bag, rectum and bone marrow were collected. Results: Of the 45 patients assessed, VMAT showed significantly lower treatment parameter values for CI (1.09 vs 1.49; p< .001) whereas, 3D-CRT showed lower Dmax (48.1Gy vs 49.2Gy; p< .001) and rectum (88.5% vs 96%). A reduced 3D-CRT dose was noted for bladder Dmax (47.4Gy vs 48.3Gy; p< .001). Conclusion: VMAT offered a superior dosimetric option, with better OAR dose sparing and optimal tumour dosimetry. 2021-01-20T13:31:49Z 2021-01-20T13:31:49Z 2020 2021-01-04T11:47:03Z Master Thesis Masters MMed http://hdl.handle.net/11427/32601 eng application/pdf Division of Radiology Faculty of Health Sciences
spellingShingle Cervical cancer
VMAT
3D-CRT
radiation therapy
dosimetry
Bhagaloo, Visham
Volumetric modulated Arc Therapy versus 3D conformal radiotherapy in the treatment of locally advanced cervical cancer. A single institution, comparative dosimetric study
thesis_degree_str Master's
title Volumetric modulated Arc Therapy versus 3D conformal radiotherapy in the treatment of locally advanced cervical cancer. A single institution, comparative dosimetric study
title_full Volumetric modulated Arc Therapy versus 3D conformal radiotherapy in the treatment of locally advanced cervical cancer. A single institution, comparative dosimetric study
title_fullStr Volumetric modulated Arc Therapy versus 3D conformal radiotherapy in the treatment of locally advanced cervical cancer. A single institution, comparative dosimetric study
title_full_unstemmed Volumetric modulated Arc Therapy versus 3D conformal radiotherapy in the treatment of locally advanced cervical cancer. A single institution, comparative dosimetric study
title_short Volumetric modulated Arc Therapy versus 3D conformal radiotherapy in the treatment of locally advanced cervical cancer. A single institution, comparative dosimetric study
title_sort volumetric modulated arc therapy versus 3d conformal radiotherapy in the treatment of locally advanced cervical cancer a single institution comparative dosimetric study
topic Cervical cancer
VMAT
3D-CRT
radiation therapy
dosimetry
url http://hdl.handle.net/11427/32601
work_keys_str_mv AT bhagaloovisham volumetricmodulatedarctherapyversus3dconformalradiotherapyinthetreatmentoflocallyadvancedcervicalcancerasingleinstitutioncomparativedosimetricstudy

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