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Pseudomonas aeruginosa bloomstream infection at a tertiary referral hospital for children
Introduction This study describes the disease burden, clinical characteristics, antibiotic management, impact of multidrug resistance and outcome of Pseudomonas aeruginosa bloodstream infection (PABSI) among children admitted to a tertiary referral hospital for children in Cape Town, South Africa. M...
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| Format: | Thesis |
| Language: | English |
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Department of Paediatrics and Child Health
2021
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| _version_ | 1867613195606163456 |
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| access_status_str | Open Access |
| author | Dame, Joycelyn Assimeng |
| author2 | Eley, Brian |
| author_browse | Dame, Joycelyn Assimeng Eley, Brian |
| author_facet | Eley, Brian Dame, Joycelyn Assimeng |
| author_sort | Dame, Joycelyn Assimeng |
| collection | Thesis |
| description | Introduction This study describes the disease burden, clinical characteristics, antibiotic management, impact of multidrug resistance and outcome of Pseudomonas aeruginosa bloodstream infection (PABSI) among children admitted to a tertiary referral hospital for children in Cape Town, South Africa. Methods A retrospective descriptive study was conducted at a paediatric referral hospital in Cape Town, South Africa. Demographic and clinical details, antibiotic management and patient outcome information were extracted from medical and laboratory records. Antibiotic susceptibility results of identified organisms were obtained from the National Health Laboratory Service database. Results The overall incidence risk of PABSI was 5.4 PABSI episodes / 10,000 hospital admissions and the most common presenting feature was respiratory distress, 34/91 (37%). Overall, 69/91 (76%) of the PA isolates were susceptible to all antipseudomonal antibiotic classes evaluated. Fifty (55%) of the PABSI episodes were treated with appropriate empiric antibiotic therapy. The mortality rate was 24% and in multivariable analysis, empiric antibiotic therapy to which PA isolate was not susceptible to, infections present on admission, and not being in the intensive care unit at the time that PABSI was diagnosed were significantly associated with 14-day mortality. Conclusion The study provided insight into factors associated with PABSI in a tertiary hospital in SubSaharan Africa. Empiric antipseudomonal antibiotic therapy was associated with a decrease in 14-day mortality. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/32633 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:17.361Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Department of Paediatrics and Child Health |
| publisherStr | Department of Paediatrics and Child Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/32633 Pseudomonas aeruginosa bloomstream infection at a tertiary referral hospital for children Dame, Joycelyn Assimeng Eley, Brian Nuttall, James Paediatric Infectious Diseases Introduction This study describes the disease burden, clinical characteristics, antibiotic management, impact of multidrug resistance and outcome of Pseudomonas aeruginosa bloodstream infection (PABSI) among children admitted to a tertiary referral hospital for children in Cape Town, South Africa. Methods A retrospective descriptive study was conducted at a paediatric referral hospital in Cape Town, South Africa. Demographic and clinical details, antibiotic management and patient outcome information were extracted from medical and laboratory records. Antibiotic susceptibility results of identified organisms were obtained from the National Health Laboratory Service database. Results The overall incidence risk of PABSI was 5.4 PABSI episodes / 10,000 hospital admissions and the most common presenting feature was respiratory distress, 34/91 (37%). Overall, 69/91 (76%) of the PA isolates were susceptible to all antipseudomonal antibiotic classes evaluated. Fifty (55%) of the PABSI episodes were treated with appropriate empiric antibiotic therapy. The mortality rate was 24% and in multivariable analysis, empiric antibiotic therapy to which PA isolate was not susceptible to, infections present on admission, and not being in the intensive care unit at the time that PABSI was diagnosed were significantly associated with 14-day mortality. Conclusion The study provided insight into factors associated with PABSI in a tertiary hospital in SubSaharan Africa. Empiric antipseudomonal antibiotic therapy was associated with a decrease in 14-day mortality. 2021-01-21T12:39:10Z 2021-01-21T12:39:10Z 2020 2021-01-21T07:51:53Z Master Thesis Masters MPhil http://hdl.handle.net/11427/32633 eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences |
| spellingShingle | Paediatric Infectious Diseases Dame, Joycelyn Assimeng Pseudomonas aeruginosa bloomstream infection at a tertiary referral hospital for children |
| thesis_degree_str | Master's |
| title | Pseudomonas aeruginosa bloomstream infection at a tertiary referral hospital for children |
| title_full | Pseudomonas aeruginosa bloomstream infection at a tertiary referral hospital for children |
| title_fullStr | Pseudomonas aeruginosa bloomstream infection at a tertiary referral hospital for children |
| title_full_unstemmed | Pseudomonas aeruginosa bloomstream infection at a tertiary referral hospital for children |
| title_short | Pseudomonas aeruginosa bloomstream infection at a tertiary referral hospital for children |
| title_sort | pseudomonas aeruginosa bloomstream infection at a tertiary referral hospital for children |
| topic | Paediatric Infectious Diseases |
| url | http://hdl.handle.net/11427/32633 |
| work_keys_str_mv | AT damejoycelynassimeng pseudomonasaeruginosabloomstreaminfectionatatertiaryreferralhospitalforchildren |