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The characterization of adaptor protein homologues in Plasmodium falciparum
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Clinical Pharmacology
2014
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| _version_ | 1867613253416255488 |
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| access_status_str | Open Access |
| author | Meredith, Sandra Allison |
| author2 | Hoppe, Heinrich C |
| author_browse | Hoppe, Heinrich C Meredith, Sandra Allison |
| author_facet | Hoppe, Heinrich C Meredith, Sandra Allison |
| author_sort | Meredith, Sandra Allison |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3291 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:12.104Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Clinical Pharmacology |
| publisherStr | Division of Clinical Pharmacology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3291 The characterization of adaptor protein homologues in Plasmodium falciparum Meredith, Sandra Allison Hoppe, Heinrich C Pharmacology Includes abstract. Includes bibliographical references (leaves 148-171). Plasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets. Components of the endocytic and secretory pathway in asexual stage parasites are attractive targets because they play a fundamental role in the normal processes of parasite metabolism. Adaptor protein complexes are components of protein coats that associate with transport vesicles of the endocytic and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The presence of these genes suggests that the parasite experiences clathrin-mediated transport processes. This study reports the cloning and characterization of selected malarial homologues of these adaptor proteins, namely three medium (μ) chain adaptin homologues and two sigma (σ) chains. 2014-07-28T18:19:16Z 2014-07-28T18:19:16Z 2009 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3291 eng application/pdf Division of Clinical Pharmacology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Pharmacology Meredith, Sandra Allison The characterization of adaptor protein homologues in Plasmodium falciparum |
| thesis_degree_str | Doctoral |
| title | The characterization of adaptor protein homologues in Plasmodium falciparum |
| title_full | The characterization of adaptor protein homologues in Plasmodium falciparum |
| title_fullStr | The characterization of adaptor protein homologues in Plasmodium falciparum |
| title_full_unstemmed | The characterization of adaptor protein homologues in Plasmodium falciparum |
| title_short | The characterization of adaptor protein homologues in Plasmodium falciparum |
| title_sort | characterization of adaptor protein homologues in plasmodium falciparum |
| topic | Pharmacology |
| url | http://hdl.handle.net/11427/3291 |
| work_keys_str_mv | AT meredithsandraallison thecharacterizationofadaptorproteinhomologuesinplasmodiumfalciparum AT meredithsandraallison characterizationofadaptorproteinhomologuesinplasmodiumfalciparum |