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Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation
Abdominal aortic aneurysms affect 0.2% of the population and are closely associated with intraluminal thromboses (ILTs) that develop in the sac. Advanced imaging and treatment techniques are available, however there is room for improvement in the methods used to predict the outcome or necessity of s...
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| Format: | Thesis |
| Language: | English |
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Department of Mechanical Engineering
2021
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| _version_ | 1867613222496894976 |
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| access_status_str | Open Access |
| author | Taylor, Mark Robin |
| author2 | Ngoepe, Malebogo |
| author_browse | Ngoepe, Malebogo Taylor, Mark Robin |
| author_facet | Ngoepe, Malebogo Taylor, Mark Robin |
| author_sort | Taylor, Mark Robin |
| collection | Thesis |
| description | Abdominal aortic aneurysms affect 0.2% of the population and are closely associated with intraluminal thromboses (ILTs) that develop in the sac. Advanced imaging and treatment techniques are available, however there is room for improvement in the methods used to predict the outcome or necessity of surgical intervention. For a computational model to be useful in this clinical setting, it would need to incorporate relevant patient-specific data and prioritise simplicity and speed over exhaustive detail. This paper presents the details of such a model, for abdominal aortic aneurysms, particularly in the simplification of the coagulation biochemistry. Explicit modelling of the coagulation cascade is replaced with a patient-specific thrombin generation curve. This curve is defined by three values obtained from a blood test. Another key feature is the thrombosis growth model, which incorporates conversion of fibrinogen to fibrin, variation between clot core and shell, and mechanical lysis. The model generates ILTs with morphologies visually similar to those typically found in the body, however more work is required to refine and validate the mode. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/33016 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:42.829Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Department of Mechanical Engineering |
| publisherStr | Department of Mechanical Engineering |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/33016 Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation Taylor, Mark Robin Ngoepe, Malebogo Engineering Abdominal aortic aneurysms affect 0.2% of the population and are closely associated with intraluminal thromboses (ILTs) that develop in the sac. Advanced imaging and treatment techniques are available, however there is room for improvement in the methods used to predict the outcome or necessity of surgical intervention. For a computational model to be useful in this clinical setting, it would need to incorporate relevant patient-specific data and prioritise simplicity and speed over exhaustive detail. This paper presents the details of such a model, for abdominal aortic aneurysms, particularly in the simplification of the coagulation biochemistry. Explicit modelling of the coagulation cascade is replaced with a patient-specific thrombin generation curve. This curve is defined by three values obtained from a blood test. Another key feature is the thrombosis growth model, which incorporates conversion of fibrinogen to fibrin, variation between clot core and shell, and mechanical lysis. The model generates ILTs with morphologies visually similar to those typically found in the body, however more work is required to refine and validate the mode. 2021-02-26T12:23:41Z 2021-02-26T12:23:41Z 2020 2021-02-26T12:22:25Z Master Thesis Masters MSc http://hdl.handle.net/11427/33016 eng application/pdf Department of Mechanical Engineering Faculty of Engineering and the Built Environment |
| spellingShingle | Engineering Taylor, Mark Robin Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation |
| thesis_degree_str | Master's |
| title | Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation |
| title_full | Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation |
| title_fullStr | Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation |
| title_full_unstemmed | Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation |
| title_short | Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation |
| title_sort | computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation |
| topic | Engineering |
| url | http://hdl.handle.net/11427/33016 |
| work_keys_str_mv | AT taylormarkrobin computationalmodelofintraluminalthrombusgrowthinabdominalaorticaneurysmswithfibringeneration |