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Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Clinical Pharmacology
2014
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| _version_ | 1867614462285971456 |
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| access_status_str | Open Access |
| author | Amlabu, Veronica Asibi |
| author2 | McIlleron, Helen |
| author_browse | Amlabu, Veronica Asibi McIlleron, Helen |
| author_facet | McIlleron, Helen Amlabu, Veronica Asibi |
| author_sort | Amlabu, Veronica Asibi |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3307 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:52:25.630Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Clinical Pharmacology |
| publisherStr | Division of Clinical Pharmacology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3307 Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children Amlabu, Veronica Asibi McIlleron, Helen Smith, Pete Pharmacology Includes abstract. Includes bibliographical references. The World Health Organization recommends the use of isoniazid preventive therapy to reduce the incidence of tuberculosis disease in populations at risk for developing the disease. Adherence to isoniazid preventive therapy is needful for efficacy. A urine assay known as the Arkansas test is widely used to monitor the ingestion of isoniazid. However, this test is limited by a drop in sensitivity with increasing time post isoniazid dose. Furthermore, results from the test can be affected by observer variation in colour changes, concomitant medications, urinary dilution, and presence of other substances in urine. Moreover, the Arkansas test results have not been evaluated against objective measurement of isoniazid and acetylisoniazid urine concentrations. This study seeks to measure the urine concentrations of isoniazid and acetylisoniazid at different time points after a dose in children, in order to establish reference ranges for liquid chromatography tandem mass spectrometry measurements of urine isoniazid and acetylisoniazid, as well as the Arkansas method. The reference ranges would provide a standard which can be used to estimate the probability of adherence to prior doses. 2014-07-28T18:21:09Z 2014-07-28T18:21:09Z 2013 Master Thesis Masters MMed http://hdl.handle.net/11427/3307 eng application/pdf Division of Clinical Pharmacology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Pharmacology Amlabu, Veronica Asibi Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children |
| thesis_degree_str | Master's |
| title | Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children |
| title_full | Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children |
| title_fullStr | Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children |
| title_full_unstemmed | Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children |
| title_short | Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children |
| title_sort | isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children |
| topic | Pharmacology |
| url | http://hdl.handle.net/11427/3307 |
| work_keys_str_mv | AT amlabuveronicaasibi isoniazidandacetylisoniazidurineconcentrationsasamakerofadherencetoisoniazidpreventativetherapyinchildren |