Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-tr...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2014
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613164405784576 |
|---|---|
| access_status_str | Open Access |
| author | Centner, Chad |
| author2 | Heckmann, Jeannine |
| author_browse | Centner, Chad Heckmann, Jeannine |
| author_facet | Heckmann, Jeannine Centner, Chad |
| author_sort | Centner, Chad |
| collection | Thesis |
| description | Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-treatment for HIV/TB, DSP risk is increased. Factors driving this risk may be vitamin B6 deficiency and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known risk |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3370 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:47.142Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3370 Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation Centner, Chad Heckmann, Jeannine Dandara, Collet Medicine Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-treatment for HIV/TB, DSP risk is increased. Factors driving this risk may be vitamin B6 deficiency and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known risk 2014-07-29T09:02:54Z 2014-07-29T09:02:54Z 2012 Master Thesis Masters MMed http://hdl.handle.net/11427/3370 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Centner, Chad Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation |
| thesis_degree_str | Master's |
| title | Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation |
| title_full | Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation |
| title_fullStr | Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation |
| title_full_unstemmed | Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation |
| title_short | Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation |
| title_sort | distal sensory polyneuropathy in hiv tb co infection the role of vitamin b6 and n acetyltransferase 2 genetic variation |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3370 |
| work_keys_str_mv | AT centnerchad distalsensorypolyneuropathyinhivtbcoinfectiontheroleofvitaminb6andnacetyltransferase2geneticvariation |