Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa
Background: Histological sampling of pulmonary lesions is important in diagnosis of lung carcinoma and affects subsequent decisions on specific management. Transthoracic CT-guided lung biopsy is considered an effective option to obtain tissue with low rates of complications, with pneumothorax being...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Radiology
2021
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867614054463307776 |
|---|---|
| access_status_str | Open Access |
| author | Richards-Edwards, William H |
| author2 | Said-Hartley, Qonita |
| author_browse | Richards-Edwards, William H Said-Hartley, Qonita |
| author_facet | Said-Hartley, Qonita Richards-Edwards, William H |
| author_sort | Richards-Edwards, William H |
| collection | Thesis |
| description | Background: Histological sampling of pulmonary lesions is important in diagnosis of lung carcinoma and affects subsequent decisions on specific management. Transthoracic CT-guided lung biopsy is considered an effective option to obtain tissue with low rates of complications, with pneumothorax being the most common. Objectives: To determine the pneumothorax rate of transthoracic CT-guided lung biopsies of focal lung lesions at Groote Schuur Hospital, and assess how procedural, patient and lesion factors influence these results. Methods: A retrospective review of 237 CT-guided lung biopsies performed over a 24-month period. Patient's CT, biopsy reports and post-procedure x-rays were reviewed. The relationship between pneumothorax rates and categorical demographic and clinical variables was analysed with Cochran's trend test. Mann-Whitney U tests were used to assess differences in continuous variables. Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary Centre in Cape Town, South Africa. Results: Pneumothorax occurred in 43 (18.1%) of the 237 biopsies. A chest drain was required in 7 of 43 pneumothoraces (16%; 3% overall). Risk factors that were significantly associated with pneumothorax rate include pleural-lesion distance (p<0.001), smaller lesion size (p=0.002), smaller needle gauge (p=0.012) and perilesional emphysema (p=0.011). Patient age, sex, position, lesion location and level of experience of the performing radiologist had no significant influence on the pneumothorax rate. Conclusion: Our post-procedure pneumothorax rate is within the acceptable range when compared to other institutions. Pleural-lesion distance, lesion size, smaller needle gauge and presence of perilesional emphysema were the most significant risk factors influencing pneumothorax rate. Knowledge of these findings may be applicable in pre-procedure planning to reduce complications and useful to local referring clinicians and patients. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/33903 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:45:56.701Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Division of Radiology |
| publisherStr | Division of Radiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/33903 Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa Richards-Edwards, William H Said-Hartley, Qonita Radiodiagnosis Background: Histological sampling of pulmonary lesions is important in diagnosis of lung carcinoma and affects subsequent decisions on specific management. Transthoracic CT-guided lung biopsy is considered an effective option to obtain tissue with low rates of complications, with pneumothorax being the most common. Objectives: To determine the pneumothorax rate of transthoracic CT-guided lung biopsies of focal lung lesions at Groote Schuur Hospital, and assess how procedural, patient and lesion factors influence these results. Methods: A retrospective review of 237 CT-guided lung biopsies performed over a 24-month period. Patient's CT, biopsy reports and post-procedure x-rays were reviewed. The relationship between pneumothorax rates and categorical demographic and clinical variables was analysed with Cochran's trend test. Mann-Whitney U tests were used to assess differences in continuous variables. Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary Centre in Cape Town, South Africa. Results: Pneumothorax occurred in 43 (18.1%) of the 237 biopsies. A chest drain was required in 7 of 43 pneumothoraces (16%; 3% overall). Risk factors that were significantly associated with pneumothorax rate include pleural-lesion distance (p<0.001), smaller lesion size (p=0.002), smaller needle gauge (p=0.012) and perilesional emphysema (p=0.011). Patient age, sex, position, lesion location and level of experience of the performing radiologist had no significant influence on the pneumothorax rate. Conclusion: Our post-procedure pneumothorax rate is within the acceptable range when compared to other institutions. Pleural-lesion distance, lesion size, smaller needle gauge and presence of perilesional emphysema were the most significant risk factors influencing pneumothorax rate. Knowledge of these findings may be applicable in pre-procedure planning to reduce complications and useful to local referring clinicians and patients. 2021-09-15T09:51:43Z 2021-09-15T09:51:43Z 2020 2021-09-15T08:32:44Z Master Thesis Masters MMed http://hdl.handle.net/11427/33903 eng application/pdf Division of Radiology Faculty of Health Sciences |
| spellingShingle | Radiodiagnosis Richards-Edwards, William H Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa |
| thesis_degree_str | Master's |
| title | Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa |
| title_full | Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa |
| title_fullStr | Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa |
| title_full_unstemmed | Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa |
| title_short | Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa |
| title_sort | factors influencing pneumothorax rates of transthoracic ct guided lung biopsies in a tertiary centre in cape town south africa |
| topic | Radiodiagnosis |
| url | http://hdl.handle.net/11427/33903 |
| work_keys_str_mv | AT richardsedwardswilliamh factorsinfluencingpneumothoraxratesoftransthoracicctguidedlungbiopsiesinatertiarycentreincapetownsouthafrica |