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High prevalence of metabolic syndrome in patients with SLE in the Western Cape
INTRODUCTION: Patients with systemic lupus erythematosus (SLE) are at increased risk of the metabolic syndrome (MetS) and its complications. In the absence of published studies from sub-Saharan Africa, we investigated the prevalence and associations of the MetS amongst recent-onset SLE patients. MET...
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2021
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| _version_ | 1867613312735248384 |
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| access_status_str | Open Access |
| author | Nkabane, Avela Ntombenkosi |
| author2 | Hodkinson, Bridget |
| author_browse | Hodkinson, Bridget Nkabane, Avela Ntombenkosi |
| author_facet | Hodkinson, Bridget Nkabane, Avela Ntombenkosi |
| author_sort | Nkabane, Avela Ntombenkosi |
| collection | Thesis |
| description | INTRODUCTION: Patients with systemic lupus erythematosus (SLE) are at increased risk of the metabolic syndrome (MetS) and its complications. In the absence of published studies from sub-Saharan Africa, we investigated the prevalence and associations of the MetS amongst recent-onset SLE patients. METHODS: A cross-sectional study of recent onset (<5 years disease duration) patients with SLE meeting the SLICC SLE classification criteria. The MetS was defined by Joint Interim Statement criteria. Clinical and demographic data and a Functional Assessment of Chronic Illness Therapy score and the 36-Item Short-Form Healthy Survey were completed. RESULTS: Of 75 patients, the mean age was 37.1 (11.7) years, disease duration was 30.8 (23.6) months, 65 (86.7%) were female, 68.0% were of mixed ethnic ancestry and 29.3% were Black Africans. The mean SLEDAI score was 0.9 (1.6). The prevalence of MetS was 40.0%, and age and body mass index were the only significant features associated with MetS (p = 0.003 and 0.001 respectively). Increased waist circumference (WC) was the most frequently observed feature, present in 92.9% of MetS patients. Patients with an elevated WC were 32.5 times more likely to have MetS. CONCLUSION: This study shows a high prevalence of MetS amongst South Africans with recently diagnosed SLE. This calls for aggressive strategies to reduce the prevalence of Mets and atherosclerotic cardiovascular disease. Waist circumference is a useful and costeffective screening tool to identify SLE patients at risk of MetS. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/33915 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:08.683Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/33915 High prevalence of metabolic syndrome in patients with SLE in the Western Cape Nkabane, Avela Ntombenkosi Hodkinson, Bridget Systemic Lupus Erythematosus Metabolic Syndrome Waist Circumference Africa INTRODUCTION: Patients with systemic lupus erythematosus (SLE) are at increased risk of the metabolic syndrome (MetS) and its complications. In the absence of published studies from sub-Saharan Africa, we investigated the prevalence and associations of the MetS amongst recent-onset SLE patients. METHODS: A cross-sectional study of recent onset (<5 years disease duration) patients with SLE meeting the SLICC SLE classification criteria. The MetS was defined by Joint Interim Statement criteria. Clinical and demographic data and a Functional Assessment of Chronic Illness Therapy score and the 36-Item Short-Form Healthy Survey were completed. RESULTS: Of 75 patients, the mean age was 37.1 (11.7) years, disease duration was 30.8 (23.6) months, 65 (86.7%) were female, 68.0% were of mixed ethnic ancestry and 29.3% were Black Africans. The mean SLEDAI score was 0.9 (1.6). The prevalence of MetS was 40.0%, and age and body mass index were the only significant features associated with MetS (p = 0.003 and 0.001 respectively). Increased waist circumference (WC) was the most frequently observed feature, present in 92.9% of MetS patients. Patients with an elevated WC were 32.5 times more likely to have MetS. CONCLUSION: This study shows a high prevalence of MetS amongst South Africans with recently diagnosed SLE. This calls for aggressive strategies to reduce the prevalence of Mets and atherosclerotic cardiovascular disease. Waist circumference is a useful and costeffective screening tool to identify SLE patients at risk of MetS. 2021-09-15T11:51:53Z 2021-09-15T11:51:53Z 2021 2021-09-15T00:47:26Z Master Thesis Masters MMed http://hdl.handle.net/11427/33915 eng application/pdf Department of Medicine Faculty of Health Sciences |
| spellingShingle | Systemic Lupus Erythematosus Metabolic Syndrome Waist Circumference Africa Nkabane, Avela Ntombenkosi High prevalence of metabolic syndrome in patients with SLE in the Western Cape |
| thesis_degree_str | Master's |
| title | High prevalence of metabolic syndrome in patients with SLE in the Western Cape |
| title_full | High prevalence of metabolic syndrome in patients with SLE in the Western Cape |
| title_fullStr | High prevalence of metabolic syndrome in patients with SLE in the Western Cape |
| title_full_unstemmed | High prevalence of metabolic syndrome in patients with SLE in the Western Cape |
| title_short | High prevalence of metabolic syndrome in patients with SLE in the Western Cape |
| title_sort | high prevalence of metabolic syndrome in patients with sle in the western cape |
| topic | Systemic Lupus Erythematosus Metabolic Syndrome Waist Circumference Africa |
| url | http://hdl.handle.net/11427/33915 |
| work_keys_str_mv | AT nkabaneavelantombenkosi highprevalenceofmetabolicsyndromeinpatientswithsleinthewesterncape |