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Population pharmacokinetic modelling for dose optimization of esomeprazole to treat early-onset preeclampsia
Rationale Esomeprazole is a proton pump inhibitor with preclinical efficacy data showing it lowers concentrations of soluble fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng), pathognomonic biomarkers identified in preeclampsia. A randomized controlled trial, Preeclampsia Intervention...
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| Format: | Thesis |
| Language: | English |
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Division of Clinical Pharmacology
2021
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