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Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species
Includes bibliographical references (leaves 73-89).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2014
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| _version_ | 1867613158430998528 |
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| access_status_str | Open Access |
| author | Lacerda, Lydia |
| author2 | Lecour, Sandrine |
| author_browse | Lacerda, Lydia Lecour, Sandrine |
| author_facet | Lecour, Sandrine Lacerda, Lydia |
| author_sort | Lacerda, Lydia |
| collection | Thesis |
| description | Includes bibliographical references (leaves 73-89). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3414 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:41.113Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3414 Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species Lacerda, Lydia Lecour, Sandrine Opie, Lionel H Medicine Includes bibliographical references (leaves 73-89). Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely understood. One potential protective pathway involves the generation of reactive oxygen species (ROS), which are known to be activated by TNFa. It was therefore hypothesized that TNFa-induced cytoprotection requires the generation of ROS. In addition, it was postulated that this ROS generation originates in the mitochondria. 2014-07-29T09:04:19Z 2014-07-29T09:04:19Z 2005 Master Thesis Masters MSc http://hdl.handle.net/11427/3414 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Lacerda, Lydia Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species |
| thesis_degree_str | Master's |
| title | Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species |
| title_full | Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species |
| title_fullStr | Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species |
| title_full_unstemmed | Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species |
| title_short | Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species |
| title_sort | signalling pathways involved in tnfα induced cytoprotection role of reactive oxygen species |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3414 |
| work_keys_str_mv | AT lacerdalydia signallingpathwaysinvolvedintnfainducedcytoprotectionroleofreactiveoxygenspecies |