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The role of IL-4Ra during acute schistosomiasis
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2014
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| _version_ | 1867613225114140672 |
|---|---|
| access_status_str | Open Access |
| author | Leeto, Mosiuoa |
| author2 | Brombacher, Frank |
| author_browse | Brombacher, Frank Leeto, Mosiuoa |
| author_facet | Brombacher, Frank Leeto, Mosiuoa |
| author_sort | Leeto, Mosiuoa |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3416 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:45.765Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3416 The role of IL-4Ra during acute schistosomiasis Leeto, Mosiuoa Brombacher, Frank Medicine Includes bibliographical references. During an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T cells, an IL-4Rα+ non-T cell effector population is required to prevent tissue pathology. The role of this dissertation was to examine the functional role of IL-Rα expression on the cells of the myeloid and lymphoid lineages during an acute Schistosoma mansoni infection and its requirement for the extent pf schistosome egg induced lung inflammation and pathology. 2014-07-29T09:06:30Z 2014-07-29T09:06:30Z 2006 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3416 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Leeto, Mosiuoa The role of IL-4Ra during acute schistosomiasis |
| thesis_degree_str | Doctoral |
| title | The role of IL-4Ra during acute schistosomiasis |
| title_full | The role of IL-4Ra during acute schistosomiasis |
| title_fullStr | The role of IL-4Ra during acute schistosomiasis |
| title_full_unstemmed | The role of IL-4Ra during acute schistosomiasis |
| title_short | The role of IL-4Ra during acute schistosomiasis |
| title_sort | role of il 4ra during acute schistosomiasis |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3416 |
| work_keys_str_mv | AT leetomosiuoa theroleofil4raduringacuteschistosomiasis AT leetomosiuoa roleofil4raduringacuteschistosomiasis |