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In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa
Bibliography: leaves 78-80.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Medicine
2014
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| _version_ | 1867613236406255616 |
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| access_status_str | Open Access |
| author | Qodi, Noluntu |
| author2 | Folb, Peter I |
| author_browse | Folb, Peter I Qodi, Noluntu |
| author_facet | Folb, Peter I Qodi, Noluntu |
| author_sort | Qodi, Noluntu |
| collection | Thesis |
| description | Bibliography: leaves 78-80. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3454 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:56.154Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3454 In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa Qodi, Noluntu Folb, Peter I Shephard, E Medicine Bibliography: leaves 78-80. Using the ethno-medicinal data approach, nine South African plants used traditionally in the treatment of malaria were collected and evaluated for cytotoxic and lymphocyte-proliferating effects. These included Acokanthera oppositofolia, Zanthoxylum capense, Glycyrrhiza glabra, Harpephyllum caffrum, Lippia javanica, Pentanisia prunneloides, Psidium guajava, Typha capensis and Cannabis sativa. The cytotoxic effect of the aqueous, methanol and dichloromethane extracts of these plants was evaluated in vitro in Rat-1 fibroblasts there was no observable difference in cytotoxic activity between cold-and hot-water extracts of all the plants investigated. Cell proliferation greater than 80% was observed for aqueous extracts of A. oppositofolia, H. caffrum, L. javanica, P. prunneloides, P. guajava and T. capensis which would suggest are considered safe for consumption. However, high cytotoxic effect was exhibited by dichloromethane extracts of Z. capense, L. javanica, C. sativa and P. guajava at 100 μg/ml. These findings suggest that dichloromethane extracted compounds that are not normally extractable by traditional methods. 2014-07-29T09:09:42Z 2014-07-29T09:09:42Z 2001 Master Thesis Masters MSc http://hdl.handle.net/11427/3454 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Qodi, Noluntu In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa |
| thesis_degree_str | Master's |
| title | In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa |
| title_full | In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa |
| title_fullStr | In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa |
| title_full_unstemmed | In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa |
| title_short | In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa |
| title_sort | in vitro tests for immunomodulatory effects of medicinal plants used in the treatment of malaria in south africa |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3454 |
| work_keys_str_mv | AT qodinoluntu invitrotestsforimmunomodulatoryeffectsofmedicinalplantsusedinthetreatmentofmalariainsouthafrica |